Concepedia

Maximum Safe Dose

Maximum Safe Dose is a pharmacological construct that denotes the highest dose of a therapeutic agent that can be administered without producing unacceptable or toxic adverse effects, thereby defining the upper boundary of the therapeutic window.

277

Publications

13.1K

Citations

1.5K

Authors

515

Institutions

Publications per year

2017–2026

56

Parents

Publications

277

Dose translation between laboratory animals and human in preclinical and clinical phases of drug development

Anroop B. Nair, Mohamed A. Morsy, Shery Jacob · Drug Development Research · 2018 · 457 citations

, , +16

A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Compare the Efficacy and Safety of Three Doses of Botulinum Toxin Type A (Dysport) With Placebo in Upper Limb Spasticity After Stroke

A. M. O. Bakheit, A. F. Thilmann, Anthony B. Ward et al. · Stroke · 2000 · 298 citations · Full text

, , +17

An epidermal growth factor receptor variant III–targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme

John H. Sampson, Gary E. Archer, Duane A. Mitchell et al. · Molecular Cancer Therapeutics · 2009 · 283 citations · Full text

, , +17

The protection of primates against soman poisoning by pretreatment with pyridostigmine

P. Dirnhuber, Mary C. French, D M Green et al. · Journal of Pharmacy and Pharmacology · 1979 · 224 citations

, , +14

Barbiturate Protection From Cerebral Infarction in Primates

Julian T. Hoff, Allan L. Smith, f HAL L. HANKINSON et al. · Stroke · 1975 · 217 citations

, , +17

1–5 of 277

Authors

1.5K

  1. PG
    Per G. Söderberg

    Karolinska Institutet, Sweden

    6 publications · 97 citations

    6

    h-index

  2. RE
    Roberto Edoardo Villa

    University of Milan, Italy

    5 publications · 81 citations

    5

    h-index

  3. VB
    Vasileios Bampidis

    Animal Welfare Institute, United States

    5 publications · 81 citations

    5

    h-index

  4. GA
    Giovanna Azimonti

    European University at Saint Petersburg, Russia

    5 publications · 81 citations

    5

    h-index

  5. MD
    Maria de Lourdes Bastos

    Universidade do Porto, Portugal

    5 publications · 81 citations

    5

    h-index

1–5 of 1.5K

Institutions

515

  1. Karolinska Institutet

    Stockholm, Sweden

    8 h-index

    29 publications

    818 citations

  2. Columbia University Irving Medical Center

    New York, United States

    6 h-index

    24 publications

    497 citations

  3. S:t Eriks Ögonsjukhus

    Stockholm, Sweden

    5 h-index

    16 publications

    437 citations

  4. Inserm

    Paris, France

    4 h-index

    5 publications

    157 citations

  5. Boston University

    Boston, United States

    4 h-index

    9 publications

    190 citations

  6. United States Food and Drug Administration

    Silver Spring, United States

    4 h-index

    5 publications

    245 citations

  7. Cornell University

    Ithaca, United States

    4 h-index

    10 publications

    696 citations

  8. University of Pittsburgh

    Pittsburgh, United States

    4 h-index

    4 publications

    168 citations

1–8 of 515

Venues

  1. PubMed

    Repository · 22 publications · 998 citations

    15

    h-index

  2. EFSA Journal

    9 publications · 256 citations

    9

    h-index

  3. PLoS ONE

    6 publications · 178 citations

    6

    h-index

  4. Journal of Biopharmaceutical Statistics

    JBS · 5 publications · 198 citations

    5

    h-index

  5. Emergency Medicine Journal

    EMJ · 4 publications · 156 citations

    4

    h-index

1–5