Concepedia

Loss-of-function Analysis

Loss-Of-Function Analysis is a reverse genetics approach that systematically disrupts gene function to determine the gene's role by observing the resulting phenotypic changes.

496

Publications

32.1K

Citations

4.6K

Authors

1.3K

Institutions

Publications per year

2017–2026

255

Variants

Loss-of-function Studies

Parents

Publications

496

A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

Daniel G. MacArthur, Suganthi Balasubramanian, Adam Frankish et al. · Science · 2012 · 1.3K citations · Full text

, , +17

Control of Effector CD8 <sup>+</sup> T Cell Function by the Transcription Factor <i>Eomesodermin</i>

Erika L. Pearce, Alan C. Mullen, Gislâine A. Martins et al. · Science · 2003 · 993 citations

, , +17

Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions

Femke Simmer, Celine Moorman, Alexander M. van der Linden et al. · PLoS Biology · 2003 · 650 citations · Full text

, , +10

A Family of IFN-γ–Inducible 65-kD GTPases Protects Against Bacterial Infection

Bae-Hoon Kim, Avinash R. Shenoy, Pradeep Kumar et al. · Science · 2011 · 495 citations

, , +17

Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus

Alexander Bolotin, Benoît Quinquis, Pierre Renault et al. · Nature Biotechnology · 2004 · 494 citations · Full text

, , +17

1–5 of 496

Authors

4.6K

  1. NM
    Nobutaka Mitsuda

    National Institute of Advanced Industrial Science and Technology, Japan

    4 publications · 118 citations

    4

    h-index

  2. MO
    Masaru Ohme‐Takagi

    National Institute of Advanced Industrial Science and Technology, Japan

    4 publications · 118 citations

    4

    h-index

  3. DY
    Didier Y. R. Stainier

    University of California, San Francisco, United States

    3 publications · 346 citations

    3

    h-index

  4. UÞ
    Unnur Þorsteinsdóttir

    deCODE Genetics (Iceland), Iceland

    3 publications · 378 citations

    3

    h-index

  5. SU
    Shizuka Uchida

    University of Louisville, United States

    3 publications · 373 citations

    3

    h-index

1–5 of 4.6K

Institutions

1.3K

  1. Harvard University

    Cambridge, United States

    21 h-index

    136 publications

    10.1K citations

  2. Sun Yat-sen University

    Guangzhou, China

    15 h-index

    116 publications

    6.5K citations

  3. Washington University in St. Louis

    St Louis, United States

    13 h-index

    31 publications

    5.6K citations

  4. Broad Institute

    Cambridge, United States

    13 h-index

    56 publications

    12.7K citations

  5. Inserm

    Paris, France

    13 h-index

    59 publications

    2.6K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    13 h-index

    45 publications

    1.6K citations

  7. Johns Hopkins University

    Baltimore, United States

    11 h-index

    34 publications

    3.5K citations

  8. Massachusetts General Hospital

    Boston, United States

    11 h-index

    32 publications

    2.1K citations

1–8 of 1.3K

Venues

  1. PLoS ONE

    23 publications · 1.3K citations

    19

    h-index

  2. Development

    21 publications · 1.6K citations

    19

    h-index

  3. Scientific Reports

    13 publications · 509 citations

    11

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 1.6K citations

    11

    h-index

  5. Cell Death and Disease

    10 publications · 513 citations

    10

    h-index

1–5