Concepedia

Loop Engineering

Loop Engineering is a protein engineering strategy that specifically targets the modification of loop regions to modulate structural flexibility, stability, and function, thereby enabling precise control over protein thermostability and conformational dynamics.

59

Publications

2.9K

Citations

290

Authors

103

Institutions

Publications per year

2017–2026

23

Parents

Publications

59

Engineering of Flexible Loops in Enzymes

Bettina M. Nestl, Bernhard Hauer · ACS Catalysis · 2014 · 232 citations

, , +14

Structure–function–folding relationship in a WW domain

Markus Jäger, Yan Zhang, Jan Bieschke et al. · Proceedings of the National Academy of Sciences · 2006 · 222 citations · Full text

, , +17

Two strategies to engineer flexible loops for improved enzyme thermostability

Haoran Yu, Yihan Yan, Cheng Zhang et al. · Scientific Reports · 2017 · 198 citations · Full text

, , +17

Picomolar Affinity Fibronectin Domains Engineered Utilizing Loop Length Diversity, Recursive Mutagenesis, and Loop Shuffling

Benjamin J. Hackel, Atul Kapila, K. Dane Wittrup · Journal of Molecular Biology · 2008 · 164 citations

, , +14

High-resolution design of a protein loop

Xiaozhen Hu, Huanchen Wang, Hengming Ke et al. · Proceedings of the National Academy of Sciences · 2007 · 126 citations · Full text

, , +15

1–5 of 59

Authors

290

  1. US
    Ulrich Schwaneberg

    RWTH Aachen University, Germany

    4 publications · 165 citations

    4

    h-index

  2. BH
    Bernhard Hauer

    University of Stuttgart, Germany

    2 publications · 327 citations

    2

    h-index

  3. LZ
    Leilei Zhu

    RWTH Aachen University, Germany

    2 publications · 76 citations

    2

    h-index

  4. SY
    Shuai You

    Chinese Academy of Agricultural Sciences, China

    2 publications · 42 citations

    2

    h-index

  5. XS
    Xavier Soberón

    Universidad Nacional Autónoma de México, Mexico

    2 publications · 72 citations

    2

    h-index

1–5 of 290

Institutions

103

  1. RWTH Aachen University

    Aachen, Germany

    4 h-index

    18 publications

    808 citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    8 publications

    984 citations

  3. Stanford University

    Stanford, United States

    3 h-index

    10 publications

    576 citations

  4. DWI – Leibniz Institute for Interactive Materials

    Aachen, Germany

    3 h-index

    7 publications

    203 citations

  5. The University of Queensland

    Brisbane, Australia

    2 h-index

    4 publications

    83 citations

  6. University of California San Diego

    San Diego, United States

    2 h-index

    4 publications

    96 citations

  7. University of Calgary

    Calgary, Canada

    2 h-index

    7 publications

    160 citations

  8. Scripps Research Institute

    San Diego, United States

    2 h-index

    8 publications

    1.1K citations

1–8 of 103

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 551 citations

    4

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 4 publications · 169 citations

    4

    h-index

  3. Journal of Molecular Biology

    JMB · 4 publications · 269 citations

    4

    h-index

  4. Biochemistry

    3 publications · 143 citations

    3

    h-index

  5. Protein Science

    PS · 3 publications · 55 citations

    3

    h-index

1–5