Concepedia

Loewe Additivity Analysis

Loewe Additivity Analysis is a formal mathematical framework used in combination antimicrobial therapy research that quantifies drug interaction effects by comparing the observed efficacy of a drug combination to the expected additive effect derived from the individual dose-response relationships, under the assumption of dose equivalence and mutual exclusivity.

38

Publications

1.9K

Citations

129

Authors

75

Institutions

Publications per year

2017–2026

15

Variants

Loewe Additivity

Parents

Publications

38

In Vitro Drug Interaction Modeling of Combinations of Azoles with Terbinafine against Clinical<i>Scedosporium prolificans</i>Isolates

Joseph Meletiadis, Johan W. Mouton, Jacques F. Meis et al. · Antimicrobial Agents and Chemotherapy · 2002 · 252 citations · Full text

, , +17

A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

Adam C. Palmer, Christopher Chidley, Peter K. Sorger · eLife · 2019 · 145 citations · Full text

, , +14

Interaction Index and Different Methods for Determining Drug Interaction in Combination Therapy

Maiying Kong, G. D. Ayers, Reuben Lotan · Journal of Biopharmaceutical Statistics · 2007 · 138 citations

, , +13

Assessing<i>in vitro</i>combinations of antifungal drugs against yeasts and filamentous fungi: comparison of different drug interaction models

Joseph Meletiadis, Paul E. Verweij, D. T. A. Te Dorsthorst et al. · Medical Mycology · 2005 · 114 citations · Full text

, , +16

Clofazimine Prevents the Regrowth of Mycobacterium abscessus and Mycobacterium avium Type Strains Exposed to Amikacin and Clarithromycin

Beatriz E. Ferro, Joseph Meletiadis, Melanie Wattenberg et al. · Antimicrobial Agents and Chemotherapy · 2015 · 112 citations · Full text

, , +17

1–5 of 38

Authors

129

  1. JW
    Johan W. Mouton

    Erasmus MC, Netherlands

    5 publications · 549 citations

    5

    h-index

  2. JM
    Joseph Meletiadis

    National and Kapodistrian University of Athens, Greece

    5 publications · 504 citations

    5

    h-index

  3. PE
    Paul E. Verweij

    Radboud University Nijmegen, Netherlands

    4 publications · 437 citations

    4

    h-index

  4. JF
    Jacques F. Meis

    Radboud University Nijmegen, Netherlands

    3 publications · 380 citations

    3

    h-index

  5. MK
    Maiying Kong

    University of Louisville, United States

    3 publications · 245 citations

    3

    h-index

1–5 of 129

Institutions

75

  1. Radboud University Nijmegen

    Nijmegen, The Netherlands

    6 h-index

    19 publications

    1.4K citations

  2. The University of Texas MD Anderson Cancer Center

    Houston, United States

    5 h-index

    9 publications

    615 citations

  3. Canisius-Wilhelmina Ziekenhuis

    Nijmegen, Netherlands

    4 h-index

    10 publications

    959 citations

  4. Uppsala University

    Uppsala, Sweden

    3 h-index

    6 publications

    87 citations

  5. Bernstein Center for Computational Neuroscience Tübingen

    Tübingen, Germany

    2 h-index

    2 publications

    151 citations

  6. University of Houston

    Houston, United States

    2 h-index

    4 publications

    161 citations

  7. Max Planck Institute for Developmental Biology

    Tübingen, Germany

    2 h-index

    2 publications

    151 citations

  8. The University of Texas Health Science Center at Houston

    Houston, United States

    2 h-index

    3 publications

    86 citations

1–8 of 75

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 5 publications · 537 citations

    5

    h-index

  2. Frontiers in Pharmacology

    3 publications · 207 citations

    3

    h-index

  3. Scientific Reports

    2 publications · 40 citations

    2

    h-index

  4. Statistics in Medicine

    2 publications · 64 citations

    2

    h-index

  5. Biometrics

    2 publications · 105 citations

    2

    h-index

1–5