Concepedia

Locus Contraction

Locus Contraction is a chromatin architectural process in which distant variable (V) gene segments of the immunoglobulin heavy chain locus are brought into spatial proximity to the diversity (D) and joining (J) gene segments through long-range genomic interactions, facilitating efficient V(D)J recombination during B-cell development.

18

Publications

1.6K

Citations

103

Authors

55

Institutions

Publications per year

2017–2026

1

Parents

Publications

18

Pax5 induces <i>V</i> -to- <i>DJ</i> rearrangements and locus contraction of the <i>immunoglobulin heavy-chain</i> gene

Martin Fuxa, Jane A. Skok, Abdallah Souabni et al. · Genes & Development · 2004 · 402 citations · Full text

, , +17

Yin Yang 1 is a critical regulator of B-cell development

Huifei Liu, Marc Schmidt‐Supprian, Yujiang Geno Shi et al. · Genes & Development · 2007 · 259 citations · Full text

, , +17

CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the <i>Igh</i> locus and antisense transcription in pro-B cells

Stephanie C. Degner, Jiyoti Verma‐Gaur, Timothy P. Wong et al. · Proceedings of the National Academy of Sciences · 2011 · 211 citations

, , +16

Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells

Camil E. Sayegh, Suchit Jhunjhunwala, Roy Riblet et al. · Genes & Development · 2005 · 190 citations · Full text

, , +17

Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire

Lindsey E. Montefiori, Robert Wuerffel, Damian Roqueiro et al. · Cell Reports · 2016 · 87 citations · Full text

, , +17

1–5 of 18

Authors

103

  1. CM
    Cornelis Murre

    University of California San Diego, United States

    3 publications · 415 citations

    3

    h-index

  2. JA
    Jane A. Skok

    New York University, United States

    3 publications · 700 citations

    3

    h-index

  3. MB
    Magdalena B. Rother

    Leiden University Medical Center, Netherlands

    3 publications · 66 citations

    3

    h-index

  4. MC
    Menno C. van Zelm

    Erasmus MC, Netherlands

    3 publications · 66 citations

    3

    h-index

  5. RR
    Roy Riblet

    Torrey Pines Institute For Molecular Studies, United States

    2 publications · 401 citations

    2

    h-index

1–5 of 103

Institutions

55

  1. University College London

    London, United Kingdom

    3 h-index

    7 publications

    2.3K citations

  2. University of California San Diego

    San Diego, United States

    3 h-index

    10 publications

    1.6K citations

  3. Erasmus MC

    Rotterdam, The Netherlands

    3 h-index

    17 publications

    370 citations

  4. Torrey Pines Institute For Molecular Studies

    San Diego, United States

    2 h-index

    6 publications

    1.2K citations

  5. University of California, Berkeley

    Berkeley, United States

    2 h-index

    7 publications

    753 citations

  6. Scripps Research Institute

    San Diego, United States

    2 h-index

    9 publications

    1.3K citations

  7. University of Illinois Chicago

    Chicago, United States

    2 h-index

    13 publications

    510 citations

  8. Tianjin Medical University

    Tianjin, China

    2 h-index

    2 publications

    74 citations

1–8 of 55

Venues

  1. The Journal of Immunology

    JI · 4 publications · 139 citations

    4

    h-index

  2. Genes & Development

    3 publications · 851 citations

    3

    h-index

  3. Scientific Reports

    1 publications · 26 citations

    1

    h-index

  4. 1

    h-index

  5. Nucleic Acids Research

    1 publications · 14 citations

    1

    h-index

1–5