Concepedia

Loading Dose Modeling

Loading Dose Modeling is a pharmacokinetic modeling approach that determines the initial dose of a drug administered intravenously to rapidly achieve a target therapeutic concentration in the bloodstream, distinguished from maintenance dose modeling by its focus on immediate drug exposure rather than sustained equilibrium levels.

32

Publications

1.3K

Citations

210

Authors

110

Institutions

Publications per year

2017–2026

12

Parents

Publications

32

Application of a Loading Dose of Colistin Methanesulfonate in Critically Ill Patients: Population Pharmacokinetics, Protein Binding, and Prediction of Bacterial Kill

Ami Fazlin Syed Mohamed, Ilias Karaiskos, Diamantis Plachouras et al. · Antimicrobial Agents and Chemotherapy · 2012 · 228 citations · Full text

, , +16

Vancomycin Dosing in Critically Ill Patients: Robust Methods for Improved Continuous-Infusion Regimens

Jason A. Roberts, Fabio Silvio Taccone, Andrew Udy et al. · Antimicrobial Agents and Chemotherapy · 2011 · 221 citations · Full text

, , +17

Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data

Rianne MF van Schie, Judith A.M. Wessels, Saskia le Cessie et al. · European Heart Journal · 2011 · 97 citations · Full text

, , +17

The paracetamol concentration‐effect relation in neonates

Karel Allegaert, Gunnar Naulaers, Sophie Vanhaesebrouck et al. · Pediatric Anesthesia · 2012 · 83 citations · Full text

, , +17

Pharmacokinetics of ε-aminocaproic Acid in Patients Undergoing Aortocoronary Bypass Surgery

John F. Butterworth, Robert L. James, Yonggu A. Lin et al. · Anesthesiology · 1999 · 63 citations · Full text

, , +11

1–5 of 32

Authors

210

  1. FJ
    Frédérique Jacobs

    Université Libre de Bruxelles, Belgium

    2 publications · 245 citations

    2

    h-index

  2. FS
    Fabio Silvio Taccone

    Université Libre de Bruxelles, Belgium

    2 publications · 245 citations

    2

    h-index

  3. GF
    Gérard Fabre

    Sanofi (France), France

    1 publications · 57 citations

    1

    h-index

  4. FR
    Frits R. Rosendaal

    Leiden University Medical Center, Netherlands

    1 publications · 97 citations

    1

    h-index

  5. AS
    Adam S. Darwich

    University of Manchester, United Kingdom

    1 publications · 10 citations

    1

    h-index

1–5 of 210

Institutions

110

  1. Inserm

    Paris, France

    2 h-index

    10 publications

    213 citations

  2. Université Libre de Bruxelles

    Brussels, Belgium

    2 h-index

    6 publications

    735 citations

  3. National Institutes of Health

    Bethesda, United States

    2 h-index

    9 publications

    201 citations

  4. National and Kapodistrian University of Athens

    Athens, Greece

    2 h-index

    13 publications

    1K citations

  5. Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

    Perm, Russia

    1 h-index

    6 publications

    72 citations

  6. Drexel University

    Philadelphia, United States

    1 h-index

    2 publications

    56 citations

  7. Menzies School of Health Research

    Darwin, Australia

    1 h-index

    1 publications

    11 citations

  8. Amphia Ziekenhuis

    Breda, The Netherlands

    1 h-index

    1 publications

    17 citations

1–8 of 110

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 5 publications · 504 citations

    5

    h-index

  2. Clinical Pharmacology & Therapeutics

    CPT · 3 publications · 71 citations

    3

    h-index

  3. Clinical Pharmacokinetics

    2 publications · 64 citations

    2

    h-index

  4. Pediatric Anesthesia

    2 publications · 93 citations

    2

    h-index

  5. International Journal of Antimicrobial Agents

    1 publications · 24 citations

    1

    h-index

1–5