Concepedia

Loading Dose Design

Loading Dose Design is a methodological framework in pharmacokinetics that determines the initial dosage of a drug required to rapidly achieve a desired steady-state concentration in the body, distinguishing it from maintenance dosing strategies by its focus on immediate therapeutic efficacy.

188

Publications

10.9K

Citations

1.2K

Authors

489

Institutions

Publications per year

2017–2026

30

Parents

Publications

188

Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes

New England Journal of Medicine · 2010 · 768 citations · Full text

, , +16

First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers

Branimir I. Šikić, Nehal J. Lakhani, Amita Patnaik et al. · Journal of Clinical Oncology · 2019 · 590 citations · Full text

, , +17

Comparison of 5-mg and 10-mg Loading Doses in Initiation of Warfarin Therapy

Linda Harrison · Annals of Internal Medicine · 1997 · 360 citations

, , +16

Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor α (infliximab) in spondyloarthropathy: an open pilot study

Filip Van den Bosch, Elli Kruithof, Dominique Baeten et al. · Annals of the Rheumatic Diseases · 2000 · 292 citations · Full text

, , +13

Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome

Søren Jepsen, P. Herlevsen, P. Knudsen et al. · Critical Care Medicine · 1992 · 252 citations

, , +17

1–5 of 188

Authors

1.2K

  1. ME
    Marie E. Rose

    University of Pittsburgh, United States

    4 publications · 176 citations

    4

    h-index

  2. RH
    Robert H. Garman

    University of Pittsburgh, United States

    4 publications · 176 citations

    4

    h-index

  3. WA
    W. Andrew Kofke

    University of Pennsylvania, United States

    4 publications · 176 citations

    4

    h-index

  4. HS
    Herbert Spapen

    Vrije Universiteit Brussel, Belgium

    3 publications · 439 citations

    3

    h-index

  5. CC
    Carl C. Hug

    Emory University, United States

    3 publications · 125 citations

    3

    h-index

1–5 of 1.2K

Institutions

489

  1. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    5 h-index

    16 publications

    386 citations

  2. Cornell University

    Ithaca, United States

    5 h-index

    21 publications

    808 citations

  3. Eli Lilly (United States)

    Indianapolis, United States

    5 h-index

    44 publications

    3.5K citations

  4. Tel Aviv University

    Tel Aviv, Israel

    4 h-index

    13 publications

    648 citations

  5. The University of Texas Southwestern Medical Center

    Dallas, United States

    4 h-index

    20 publications

    785 citations

  6. Johns Hopkins University

    Baltimore, United States

    3 h-index

    8 publications

    169 citations

  7. Stanford University

    Stanford, United States

    3 h-index

    25 publications

    8.4K citations

  8. Medical University of Vienna

    Vienna, Austria

    3 h-index

    9 publications

    155 citations

1–8 of 489

Venues

  1. PubMed

    Repository · 13 publications · 368 citations

    10

    h-index

  2. Journal of Clinical Oncology

    11 publications · 1.2K citations

    10

    h-index

  3. Antimicrobial Agents and Chemotherapy

    AAC · 9 publications · 419 citations

    9

    h-index

  4. Anesthesia & Analgesia

    9 publications · 377 citations

    8

    h-index

  5. Clinical Pharmacology & Therapeutics

    CPT · 6 publications · 140 citations

    6

    h-index

1–5