Herbert Spapen

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current  -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

Jason A. Roberts, Sanjoy K. Paul, Murat Akova et al. · Clinical Infectious Diseases · 2014 · 1.1K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) in Severe Sepsis

Edward Abraham, Konrad Reinhart, Steven M. Opal et al. · JAMA · 2003 · 957 citations

Medicine, Pharmacology, Pharmacotherapy +15

High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial

Olivier Joannès-Boyau, Patrick M. Honoré, Paul Perez et al. · Intensive Care Medicine · 2013 · 417 citations

Medicine, Nephrology, Hemodialysis +12

Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

Fabio Silvio Taccone, Pierre‐François Laterre, Thierry Dugernier et al. · Critical Care · 2010 · 372 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Cardiac Troponins I and T Are Biological Markers of Left Ventricular Dysfunction in Septic Shock

Kristien M. ver Elst, Herbert Spapen, Duc Nam Nguyen et al. · Clinical Chemistry · 2000 · 325 citations

Veterinary Medicine, Cardiology, Physiology +15