Concepedia

Lipoplex Escape

Lipoplex Escape is a mechanism in gene delivery whereby a lipoplex, a complex of cationic lipids and nucleic acids, escapes from the endosomal compartment into the cytoplasm through lipid-mediated membrane destabilization, distinguishing it from other endosomal escape strategies by its reliance on cationic lipid-nucleic acid interactions and non-covalent assembly.

5

Publications

598

Citations

28

Authors

16

Institutions

Publications per year

2017–2026

1

Parents

Publications

5

Transfection Mediated by Gemini Surfactants:  Engineered Escape from the Endosomal Compartment

Paul C. Bell, Mark Bergsma, Igor P. Dolbnya et al. · Journal of the American Chemical Society · 2003 · 217 citations

, , +17

The Role of the Helper Lipid on the DNA Transfection Efficiency of Lipopolyplex Formulations

Zixiu Du, Mustafa M. Munye, Aristides D. Tagalakis et al. · Scientific Reports · 2014 · 191 citations · Full text

, , +17

A molecular view on the escape of lipoplexed DNA from the endosome

Bart M. H. Bruininks, Paulo CT Souza, Helgi I. Ingólfsson et al. · eLife · 2020 · 88 citations · Full text

, , +17

Probing the in vitro mechanism of action of cationic lipid/DNA lipoplexes at a nanometric scale

Olivier Le Bihan, Raphaël Chèvre, Stéphane Mornet et al. · Nucleic Acids Research · 2010 · 57 citations · Full text

, , +17

Efficient Escape from Endosomes Determines the Superior Efficiency of Multicomponent Lipoplexes

Giulio Caracciolo, Ruggero Caminiti, Michelle A. Digman et al. · The Journal of Physical Chemistry B · 2009 · 45 citations · Full text

, , +17

1–5 of 5

Authors

28

  1. OL
    Olivier Le Bihan

    Institut national de l'environnement industriel et des risques, France

    1 publications · 57 citations

    1

    h-index

  2. MA
    Michelle A. Digman

    University of California, Irvine, United States

    1 publications · 45 citations

    1

    h-index

  3. BM
    Bart M. H. Bruininks

    University of Groningen, Netherlands

    1 publications · 88 citations

    1

    h-index

  4. MB
    Mark Bergsma

    University of Groningen, Netherlands

    1 publications · 217 citations

    1

    h-index

  5. RC
    Ruggero Caminiti

    Sapienza University of Rome, Italy

    1 publications · 45 citations

    1

    h-index

1–5 of 28

Institutions

16

  1. University of Groningen

    Groningen, The Netherlands

    2 h-index

    12 publications

    2.1K citations

  2. Chimie et Biologie des Membranes et des Nanoobjects

    Pessac, France

    1 h-index

    3 publications

    171 citations

  3. Institut National Polytechnique de Toulouse

    Toulouse, France

    1 h-index

    6 publications

    342 citations

  4. Institut Européen de Chimie et Biologie

    Pessac, France

    1 h-index

    6 publications

    342 citations

  5. Sapienza University of Rome

    Rome, Italy

    1 h-index

    5 publications

    225 citations

  6. Fluor (United States)

    Irving, United States

    1 h-index

    4 publications

    180 citations

  7. Institut de Chimie de la Matière Condensée de Bordeaux

    Pessac, France

    1 h-index

    1 publications

    57 citations

  8. Tel Aviv University

    Tel Aviv, Israel

    1 h-index

    2 publications

    176 citations

1–8 of 16

Venues

  1. Journal of the American Chemical Society

    JACS · 1 publications · 217 citations

    1

    h-index

  2. Scientific Reports

    1 publications · 191 citations

    1

    h-index

  3. The Journal of Physical Chemistry B

    1 publications · 45 citations

    1

    h-index

  4. eLife

    1 publications · 88 citations

    1

    h-index

  5. Nucleic Acids Research

    1 publications · 57 citations

    1

    h-index

1–5