Concepedia

Linear Clearance

Linear Clearance is a pharmacokinetic parameter representing the volume of plasma from which a drug is completely removed per unit time under conditions where the clearance remains constant and independent of drug concentration, distinguishing it from nonlinear clearance mechanisms.

31

Publications

1.2K

Citations

204

Authors

76

Institutions

Publications per year

2017–2026

11

Parents

Publications

31

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Yanan Zheng, Devin B. Tesar, Lisa J. Benincosa et al. · mAbs · 2012 · 144 citations · Full text

, , +17

Population Pharmacokinetic Analysis of Panitumumab in Patients With Advanced Solid Tumors

Peiming Ma, Bingbing Yang, Yow‐Ming Wang et al. · The Journal of Clinical Pharmacology · 2009 · 85 citations

, , +17

Population Pharmacokinetics of Obinutuzumab (GA101) in Chronic Lymphocytic Leukemia (CLL) and Non‐Hodgkin's Lymphoma and Exposure–Response in CLL

Ekaterina Gibiansky, Leonid Gibiansky, David Carlile et al. · CPT Pharmacometrics & Systems Pharmacology · 2014 · 85 citations · Full text

, , +17

Population pharmacokinetics of rituximab in patients with diffuse large B‐cell lymphoma and association with clinical outcome

Samo Rožman, Iztok Grabnar, Srdjan Novaković et al. · British Journal of Clinical Pharmacology · 2017 · 52 citations · Full text

, , +17

Identifying biophysical assays and <i>in silico</i> properties that enrich for slow clearance in clinical-stage therapeutic antibodies

Boris Grinshpun, Nels Thorsteinson, Joao NS Pereira et al. · mAbs · 2021 · 52 citations · Full text

, , +14

1–5 of 31

Authors

204

  1. AJ
    Amita Joshi

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    2 publications · 182 citations

    2

    h-index

  2. JY
    Jin Y. Jin

    Roche (Switzerland), Switzerland

    2 publications · 73 citations

    2

    h-index

  3. LG
    Leonid Gibiansky

    Princeton University, United States

    2 publications · 122 citations

    2

    h-index

  4. DE
    Donald E. Mager

    University at Buffalo, State University of New York, United States

    2 publications · 83 citations

    2

    h-index

  5. NJ
    Nicole Justies

    Roche (Switzerland), Switzerland

    1 publications · 144 citations

    1

    h-index

1–5 of 204

Institutions

76

  1. University of Ljubljana

    Ljubljana, Slovenia

    2 h-index

    4 publications

    180 citations

  2. Roche (Switzerland)

    Basel, Switzerland

    2 h-index

    13 publications

    1.7K citations

  3. Bristol-Myers Squibb (Germany)

    Munich, Germany

    2 h-index

    5 publications

    129 citations

  4. University of Pittsburgh

    Pittsburgh, United States

    2 h-index

    6 publications

    148 citations

  5. Bristol-Myers Squibb (United States)

    New York, United States

    2 h-index

    2 publications

    57 citations

  6. Uppsala University

    Uppsala, Sweden

    2 h-index

    3 publications

    120 citations

  7. Amgen (United States)

    Thousand Oaks, United States

    2 h-index

    9 publications

    629 citations

  8. Certara (United States)

    St Louis, United States

    2 h-index

    5 publications

    126 citations

1–8 of 76

Venues

  1. The Journal of Clinical Pharmacology

    5 publications · 200 citations

    5

    h-index

  2. British Journal of Clinical Pharmacology

    BJCP · 4 publications · 152 citations

    4

    h-index

  3. CPT Pharmacometrics & Systems Pharmacology

    PSP · 3 publications · 139 citations

    3

    h-index

  4. mAbs

    2 publications · 196 citations

    2

    h-index

  5. Clinical and Translational Science

    CTS · 2 publications · 53 citations

    2

    h-index

1–5