Concepedia

Ligation Fidelity

Ligation Fidelity is a performance metric that quantifies the accuracy with which DNA ligase catalyzes the formation of phosphodiester bonds exclusively between correctly base-paired adjacent nucleotides during DNA ligation.

73

Publications

3.9K

Citations

249

Authors

93

Institutions

Publications per year

2017–2026

20

Parents

Publications

73

The ligation amplification reaction (LAR)—Amplification of specific DNA sequences using sequential rounds of template-dependent ligation

Dan Y. Wu, R. Bruce Wallace · Genomics · 1989 · 261 citations

, , +10

Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution

Lars Abrahmsén, Jeffrey Tom, John P. Burnier et al. · Biochemistry · 1991 · 247 citations

, , +15

Comprehensive Profiling of Four Base Overhang Ligation Fidelity by T4 DNA Ligase and Application to DNA Assembly

Jennifer L. Ong, Rebecca Kucera, Bradley W. Langhorst et al. · ACS Synthetic Biology · 2018 · 214 citations · Full text

, , +16

Structural bias in T4 RNA ligase-mediated 3′-adapter ligation

Fanglei Zhuang, Ryan T. Fuchs, Zhiyi Sun et al. · Nucleic Acids Research · 2012 · 202 citations · Full text

, , +13

Improving the fidelity of Thermus thermophilus DNA ligase

Juan Luo · Nucleic Acids Research · 1996 · 193 citations

, , +16

1–5 of 73

Authors

249

  1. GJ
    Gregory J. S. Lohman

    New England Biolabs (United States), United States

    6 publications · 504 citations

    6

    h-index

  2. TC
    Thomas C. Evans

    New England Biolabs (United States), United States

    4 publications · 437 citations

    4

    h-index

  3. LE
    Leslie E. Orgel

    Salk Institute for Biological Studies, United States

    4 publications · 143 citations

    4

    h-index

  4. JM
    John M. Pryor

    University of North Carolina at Chapel Hill, United States

    3 publications · 332 citations

    3

    h-index

  5. KB
    Katharina Bilotti

    New England Biolabs (United States), United States

    3 publications · 299 citations

    3

    h-index

1–5 of 249

Institutions

93

  1. New England Biolabs (United States)

    Ipswich, United States

    7 h-index

    40 publications

    4.3K citations

  2. Kettering University

    Flint, United States

    4 h-index

    7 publications

    212 citations

  3. Cornell University

    Ithaca, United States

    4 h-index

    7 publications

    679 citations

  4. Salk Institute for Biological Studies

    La Jolla, United States

    3 h-index

    8 publications

    331 citations

  5. Hearst (United States)

    New York, United States

    3 h-index

    6 publications

    486 citations

  6. National Institutes of Health

    Bethesda, United States

    3 h-index

    11 publications

    524 citations

  7. University of Michigan

    Ann Arbor, United States

    2 h-index

    6 publications

    300 citations

  8. Karlsruhe Institute of Technology

    Karlsruhe, Germany

    2 h-index

    4 publications

    78 citations

1–8 of 93

Venues

  1. Nucleic Acids Research

    17 publications · 1.3K citations

    16

    h-index

  2. ChemBioChem

    4 publications · 139 citations

    4

    h-index

  3. Journal of the American Chemical Society

    JACS · 3 publications · 99 citations

    4

    h-index

  4. Analytical Biochemistry

    3 publications · 80 citations

    3

    h-index

  5. Chemical Communications

    ChemComm · 3 publications · 150 citations

    3

    h-index

1–5