Concepedia

Ligase Substrate Specificity

Ligase Substrate Specificity is a biochemical property that defines the selective capacity of a DNA ligase enzyme to catalyze phosphodiester bond formation preferentially between particular nucleic acid substrates based on structural, sequence, or conformational features of the DNA ends.

176

Publications

11.4K

Citations

830

Authors

261

Institutions

Publications per year

2017–2026

40

Parents

Publications

176

Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF <sup>Fbw7</sup> Ubiquitin Ligase

Deanna M. Koepp, Laura Schaefer, Xin Ye et al. · Science · 2001 · 760 citations · Full text

, , +17

Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

Giang K. T. Nguyen, Shujing Wang, Yibo Qiu et al. · Nature Chemical Biology · 2014 · 430 citations

, , +9

Global Identification of Modular Cullin-RING Ligase Substrates

Michael J. Emanuele, Andrew E. H. Elia, Qikai Xu et al. · Cell · 2011 · 405 citations · Full text

, , +12

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Kuan‐Chuan Pao, Nicola T. Wood, Axel Knebel et al. · Nature · 2018 · 294 citations · Full text

, , +10

An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

Yang Li, Ping Xie, Lu Liang et al. · Nature Communications · 2017 · 252 citations · Full text

, , +11

1–5 of 176

Authors

830

  1. SS
    Stewart Shuman

    Kettering University, United States

    12 publications · 926 citations

    12

    h-index

  2. AE
    Alan E. Tomkinson

    University of Maryland, Baltimore, United States

    6 publications · 570 citations

    6

    h-index

  3. VS
    Verl Sriskanda

    Kettering University, United States

    5 publications · 354 citations

    5

    h-index

  4. SJ
    Stephen J. Elledge

    Howard Hughes Medical Institute, United States

    4 publications · 1.3K citations

    4

    h-index

  5. TL
    Tomas Lindahl

    Linköping University, Sweden

    4 publications · 424 citations

    4

    h-index

1–5 of 830

Institutions

261

  1. Kettering University

    Flint, United States

    19 h-index

    42 publications

    2.8K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    9 h-index

    25 publications

    6.3K citations

  3. Harvard University

    Cambridge, United States

    8 h-index

    37 publications

    5.9K citations

  4. Albert Einstein College of Medicine

    Bronx, United States

    5 h-index

    10 publications

    264 citations

  5. Istituto di Genetica Molecolare

    Pavia, Italy

    4 h-index

    10 publications

    392 citations

  6. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    4 h-index

    13 publications

    661 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    11 publications

    310 citations

  8. National Institutes of Health

    Bethesda, United States

    4 h-index

    9 publications

    805 citations

1–8 of 261

Venues

  1. Journal of Biological Chemistry

    JBC · 31 publications · 2.1K citations

    27

    h-index

  2. Nucleic Acids Research

    15 publications · 651 citations

    14

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 646 citations

    11

    h-index

  4. European Journal of Biochemistry

    EJB · 7 publications · 270 citations

    7

    h-index

  5. FEBS Letters

    5 publications · 166 citations

    5

    h-index

1–5