Concepedia

Ligand-receptor Binding Engineering

Ligand-Receptor Binding Engineering is a methodological framework within protein-protein interaction engineering that specifically focuses on the rational design and optimization of molecular interfaces to enhance or modulate the specificity, affinity, and functional outcomes of ligand-receptor binding events.

58

Publications

2.4K

Citations

435

Authors

118

Institutions

Publications per year

2017–2026

16

Parents

Publications

58

DNA Framework-Programmed Cell Capture via Topology-Engineered Receptor–Ligand Interactions

Min Li, Hong‐Ming Ding, Meihua Lin et al. · Journal of the American Chemical Society · 2019 · 187 citations

, , +17

Protein Surface Recognition by Synthetic Receptors:  A Route to Novel Submicromolar Inhibitors for α-Chymotrypsin

Hyung Soon Park, Qing Lin, Andrew D. Hamilton · Journal of the American Chemical Society · 1998 · 185 citations

, , +17

Mapping the Ligand-Binding Site on a G Protein-Coupled Receptor (GPCR) Using Genetically Encoded Photocrosslinkers

Amy Grunbeck, Thomas Huber, Thomas P. Sakmar · Biochemistry · 2011 · 115 citations · Full text

, , +17

Crystal structures of NK1–heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor

Daniel Lietha, Dimitri Y. Chirgadze, Barbara Mulloy et al. · The EMBO Journal · 2001 · 112 citations · Full text

, , +17

Evaluation of a Catenary PBPK Model for Predicting the In Vivo Disposition of mAbs Engineered for High-Affinity Binding to FcRn

Yang Chen, Joseph P. Balthasar · The AAPS Journal · 2012 · 103 citations · Full text

, , +17

1–5 of 58

Authors

435

  1. DB
    David Baker

    University of Washington, United States

    2 publications · 107 citations

    2

    h-index

  2. BM
    Bernadette M. Dutia

    University of Edinburgh, United Kingdom

    1 publications · 40 citations

    1

    h-index

  3. DL
    Daniel Lietha

    Spanish National Cancer Research Centre, Spain

    1 publications · 112 citations

    1

    h-index

  4. MW
    Matthias Wittwer

    University of Bern, Switzerland

    1 publications · 54 citations

    1

    h-index

  5. MT
    Masayuki Tsuchiya

    Chugai Pharma (United States), United States

    1 publications · 36 citations

    1

    h-index

1–5 of 435

Institutions

118

  1. University of Oxford

    Oxford, United Kingdom

    2 h-index

    18 publications

    506 citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    9 publications

    484 citations

  3. Shanghai Jiao Tong University

    Shanghai, China

    2 h-index

    19 publications

    1.6K citations

  4. University of California San Diego

    San Diego, United States

    2 h-index

    2 publications

    36 citations

  5. Renji Hospital

    Shanghai, China

    2 h-index

    11 publications

    1.5K citations

  6. University of Cambridge

    Cambridge, United Kingdom

    2 h-index

    6 publications

    340 citations

  7. University of Washington

    Seattle, United States

    2 h-index

    17 publications

    903 citations

  8. Novo Nordisk (United States)

    Seattle, United States

    1 h-index

    1 publications

    38 citations

1–8 of 118

Venues

  1. Journal of the American Chemical Society

    JACS · 4 publications · 448 citations

    4

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 90 citations

    3

    h-index

  3. Angewandte Chemie International Edition

    3 publications · 79 citations

    3

    h-index

  4. Nature Communications

    3 publications · 87 citations

    3

    h-index

  5. Bioconjugate Chemistry

    3 publications · 65 citations

    3

    h-index

1–5