Concepedia

Ligand-mediated Release

Ligand-Mediated Release is a controlled release mechanism in which the targeted and selective delivery of a therapeutic agent is achieved through the specific binding interaction between a ligand conjugated to the drug carrier and its corresponding receptor on the target cell or tissue.

127

Publications

10.7K

Citations

707

Authors

273

Institutions

Publications per year

2017–2026

31

Parents

Publications

127

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Eric H. Schroeter, Jeffrey A. Kisslinger, Raphael Kopan · Nature · 1998 · 1.6K citations

, , +13

Metalloproteinase-mediated release of human Fas ligand.

Nobuhiko Kayagaki, Tomohiko Ebata, Hiroshi Ohmoto et al. · The Journal of Experimental Medicine · 1995 · 831 citations · Full text

, , +15

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

Ron M. Versteegen, Raffaella Rossin, Wolter ten Hoeve et al. · Angewandte Chemie International Edition · 2013 · 441 citations

, , +16

Selective Impairment of TLR-Mediated Innate Immunity in Human Newborns: Neonatal Blood Plasma Reduces Monocyte TNF-α Induction by Bacterial Lipopeptides, Lipopolysaccharide, and Imiquimod, but Preserves the Response to R-848

Ofer Levy, Kol A. Zarember, René M. Roy et al. · The Journal of Immunology · 2004 · 377 citations · Full text

, , +17

Substrate Selectivity of Epidermal Growth Factor-Receptor Ligand Sheddases and their Regulation by Phorbol Esters and Calcium Influx

Keisuke Horiuchi, Sylvain Le Gall, Marc Schulte et al. · Molecular Biology of the Cell · 2006 · 309 citations · Full text

, , +13

1–5 of 127

Authors

707

  1. HW
    H Wiley

    Pacific Northwest National Laboratory, United States

    4 publications · 452 citations

    4

    h-index

  2. HK
    Hisataka Kobayashi

    National Cancer Institute, United States

    3 publications · 309 citations

    3

    h-index

  3. DA
    Douglas A. Lauffenburger

    Massachusetts Institute of Technology, United States

    3 publications · 378 citations

    3

    h-index

  4. PJ
    Peter J. Dempsey

    Vanderbilt University, United States

    3 publications · 557 citations

    3

    h-index

  5. PL
    Peter L. Choyke

    National Cancer Institute, United States

    3 publications · 309 citations

    3

    h-index

1–5 of 707

Institutions

273

  1. Harvard University

    Cambridge, United States

    7 h-index

    19 publications

    2.2K citations

  2. Center for Cancer Research

    Bethesda, United States

    5 h-index

    30 publications

    3.7K citations

  3. University of Oxford

    Oxford, United Kingdom

    3 h-index

    9 publications

    816 citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    18 publications

    1.3K citations

  5. University of Huddersfield

    Huddersfield, United Kingdom

    3 h-index

    12 publications

    318 citations

  6. KU Leuven

    Leuven, Belgium

    3 h-index

    7 publications

    606 citations

  7. The University of Sydney

    Sydney, Australia

    3 h-index

    7 publications

    365 citations

  8. National Institutes of Health

    Bethesda, United States

    3 h-index

    15 publications

    1.8K citations

1–8 of 273

Venues

  1. Journal of Biological Chemistry

    JBC · 8 publications · 821 citations

    8

    h-index

  2. Biochemistry

    8 publications · 236 citations

    8

    h-index

  3. Dalton Transactions

    5 publications · 136 citations

    5

    h-index

  4. Nature Communications

    5 publications · 235 citations

    5

    h-index

  5. Inorganic Chemistry

    4 publications · 180 citations

    4

    h-index

1–5