Concepedia

Ligand Tissue Selectivity

Ligand Tissue Selectivity is a pharmacological property that refers to the preferential binding or functional activity of a ligand in specific tissue types due to the differential expression or conformation of target receptors, enabling tissue-specific therapeutic effects.

98

Publications

5.9K

Citations

528

Authors

111

Institutions

Publications per year

2017–2026

6

Parents

Publications

98

Molecular determinants of tissue selectivity in estrogen receptor modulators

Timothy A. Grese, James P. Sluka, Henry U. Bryant et al. · Proceedings of the National Academy of Sciences · 1997 · 243 citations

, , +17

Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity.

T Dennis, Alain Fournier, S. St. Pierre et al. · Journal of Pharmacology and Experimental Therapeutics · 1989 · 228 citations

, , +17

Conformational Changes and Coactivator Recruitment by Novel Ligands for Estrogen Receptor-α and Estrogen Receptor-β: Correlations with Biological Character and Distinct Differences among SRC Coactivator Family Members*

Dennis M. Kraichely, Jun Sun, John A. Katzenellenbogen et al. · Endocrinology · 2000 · 217 citations

, , +17

Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish ( <i>Carassius auratus</i> )

Nicola Illing, Brigitte E. Troskie, Carol S. Nahorniak et al. · Proceedings of the National Academy of Sciences · 1999 · 193 citations · Full text

, , +17

RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer

Cory Iverson, Gary Larson, Chon Lai et al. · Cancer Research · 2009 · 183 citations · Full text

, , +17

1–5 of 98

Authors

528

  1. PL
    Philippe Lebrun

    Université Libre de Bruxelles, Belgium

    6 publications · 233 citations

    6

    h-index

  2. BP
    Bernard Pirotte

    University of Liège, Belgium

    6 publications · 233 citations

    6

    h-index

  3. PD
    Pascal De Tullio

    University of Liège, Belgium

    5 publications · 192 citations

    5

    h-index

  4. RQ
    Rémi Quirion

    Douglas Mental Health University Institute, Canada

    4 publications · 311 citations

    4

    h-index

  5. BB
    Bénédicte Becker

    Université Libre de Bruxelles, Belgium

    4 publications · 167 citations

    4

    h-index

1–5 of 528

Institutions

111

  1. University of Liège

    Liège, Belgium

    6 h-index

    41 publications

    1.8K citations

  2. Université Libre de Bruxelles

    Brussels, Belgium

    5 h-index

    37 publications

    1.7K citations

  3. Eli Lilly (United States)

    Indianapolis, United States

    5 h-index

    48 publications

    6.3K citations

  4. Douglas Mental Health University Institute

    Montreal, Canada

    4 h-index

    12 publications

    1.3K citations

  5. National Institute on Drug Abuse

    Bethesda, United States

    4 h-index

    20 publications

    513 citations

  6. Utrecht University

    Utrecht, The Netherlands

    3 h-index

    12 publications

    606 citations

  7. Douglas College

    New Westminster, Canada

    3 h-index

    6 publications

    982 citations

  8. McGill University

    Montreal, Canada

    3 h-index

    9 publications

    376 citations

1–8 of 111

Venues

  1. Journal of Medicinal Chemistry

    13 publications · 669 citations

    13

    h-index

  2. PubMed

    Repository · 12 publications · 401 citations

    12

    h-index

  3. 10

    h-index

  4. British Journal of Pharmacology

    BJP · 7 publications · 364 citations

    7

    h-index

  5. Endocrinology

    5 publications · 594 citations

    5

    h-index

1–5