F. Somers

4<i>H</i>-1,2,4-Pyridothiadiazine 1,1-Dioxides and 2,3-Dihydro-4<i>H</i>-1,2,4-pyridothiadiazine 1,1-Dioxides Chemically Related to Diazoxide and Cyclothiazide as Powerful Positive Allosteric Modulators of (<i>R</i>/<i>S</i>)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors:  Design, Synthesis, Pharmacology, and Structure−Activity Relationships

Bernard Pirotte, Tchao Podona, Ousmane Diouf et al. · Journal of Medicinal Chemistry · 1998 · 60 citations

Ampa Receptor Modulator, Pharmacotherapy, Chemistry +19

Toward Tissue-Selective Pancreatic B-Cells K_ATP Channel Openers Belonging to 3-Alkylamino-7-halo-4<i>H</i>-1,2,4-benzothiadiazine 1,1-Dioxides

Pascal De Tullio, Bénédicte Becker, S. Boverie et al. · Journal of Medicinal Chemistry · 2003 · 57 citations

Effect on<i>K</i>_ATPChannel Activation Properties and Tissue Selectivity of the Nature of the Substituent in the 7- and the 3-Position of 4<i>H</i>-1,2,4-Benzothiadiazine 1,1-Dioxides

S. Boverie, Marie‐Hélène Antoine, F. Somers et al. · Journal of Medicinal Chemistry · 2005 · 53 citations

3-Alkylamino-4<i>H</i>-pyrido[2,3-<i>e</i>]-1,2,4-thiadiazine 1,1-Dioxides Structurally Related to Diazoxide and Pinacidil as Potassium Channel Openers Acting on Vascular Smooth Muscle Cells:  Design, Synthesis, and Pharmacological Evaluation

Bernard Pirotte, R. Ouedraogo, Pascal De Tullio et al. · Journal of Medicinal Chemistry · 2000 · 40 citations

Original 2-Alkylamino-6-halogenoquinazolin-4(3<i>H</i>)-ones and K_ATP Channel Activity

F. Somers, R. Ouedraogo, Marie‐Hélène Antoine et al. · Journal of Medicinal Chemistry · 2001 · 33 citations

Bioorganic Chemistry, Molecular Biology, Chemical Biology +16