Concepedia

Ligand Secretion

Ligand Secretion is a cellular mechanism in intercellular signaling pathways, specifically within autocrine and Hedgehog signaling systems, that involves the regulated release of diffusible signaling molecules by a cell to initiate receptor-mediated responses in the same or neighboring cells.

46

Publications

5.7K

Citations

323

Authors

131

Institutions

Publications per year

2017–2026

14

Parents

Publications

46

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

Samuel Davis, Thomas H. Aldrich, Pamela F. Jones et al. · Cell · 1996 · 2K citations · Full text

, , +12

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Jun Liu, Shifeng Pan, Mindy H. Hsieh et al. · Proceedings of the National Academy of Sciences · 2013 · 835 citations · Full text

, , +16

Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum

Yugo Habata, Ryo Fujii, Masaki Hosoya et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 1999 · 350 citations

, , +12

Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

Peggy Myung, Makoto Takeo, Mayumi Ito et al. · Journal of Investigative Dermatology · 2012 · 238 citations · Full text

, , +14

Deletion of mouse <i>Porcn</i> blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome

Jared J. Barrott, Gabriela M Cash, Aaron P. Smith et al. · Proceedings of the National Academy of Sciences · 2011 · 176 citations · Full text

, , +17

1–5 of 46

Authors

323

  1. MI
    Mayumi Ito

    New York University, United States

    3 publications · 345 citations

    3

    h-index

  2. MT
    Makoto Takeo

    New York University, United States

    3 publications · 345 citations

    3

    h-index

  3. DA
    Douglas A. Lauffenburger

    Massachusetts Institute of Technology, United States

    3 publications · 69 citations

    3

    h-index

  4. HW
    H Wiley

    Pacific Northwest National Laboratory, United States

    2 publications · 46 citations

    2

    h-index

  5. ME
    Margaret E. McLaughlin

    Massachusetts Institute of Technology, United States

    2 publications · 953 citations

    2

    h-index

1–5 of 323

Institutions

131

  1. University of Utah

    Salt Lake City, United States

    4 h-index

    7 publications

    702 citations

  2. New York University

    New York, United States

    3 h-index

    13 publications

    1.2K citations

  3. Case Western Reserve University

    Cleveland, United States

    2 h-index

    6 publications

    704 citations

  4. University of Illinois Urbana-Champaign

    Urbana, United States

    2 h-index

    2 publications

    37 citations

  5. Weizmann Institute of Science

    Rehovot, Israel

    2 h-index

    10 publications

    758 citations

  6. National Institutes of Health

    Bethesda, United States

    2 h-index

    6 publications

    246 citations

  7. University of California, San Francisco

    San Francisco, United States

    2 h-index

    6 publications

    644 citations

  8. University of Michigan

    Ann Arbor, United States

    2 h-index

    9 publications

    3.5K citations

1–8 of 131

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 1K citations

    4

    h-index

  2. eLife

    3 publications · 177 citations

    3

    h-index

  3. Journal of Investigative Dermatology

    JID · 2 publications · 257 citations

    2

    h-index

  4. PLoS ONE

    2 publications · 46 citations

    2

    h-index

  5. Cell

    2 publications · 2.1K citations

    2

    h-index

1–5