Concepedia

Ligand Clustering

Ligand Clustering is a multivalent interaction mechanism in which multiple ligands are spatially organized into discrete assemblies on a scaffold or surface, enhancing binding affinity and specificity through cooperative interactions with target receptors.

87

Publications

5.6K

Citations

389

Authors

192

Institutions

Publications per year

2017–2026

27

Parents

Publications

87

Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand Architecture

Jason E. Gestwicki, Christopher W. Cairo, Laura E. Strong et al. · Journal of the American Chemical Society · 2002 · 699 citations

, , +16

Receptor clustering as a cellular mechanism to control sensitivity

Dennis Bray, Matthew D. Levin, Carl J. Morton-Firth · Nature · 1998 · 625 citations

, , +13

FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness

Hyun Joon Kong, Thomas R. Polte, Eben Alsberg et al. · Proceedings of the National Academy of Sciences · 2005 · 304 citations · Full text

, , +17

The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro.

I.V. Fuki, Karsten Kuhn, I R Lomazov et al. · Journal of Clinical Investigation · 1997 · 239 citations · Full text

, , +14

Cooperative and non-cooperative binding of large ligands to a finite one-dimensional lattice

Irving R. Epstein · Biophysical Chemistry · 1978 · 200 citations

, , +16

1–5 of 87

Authors

389

  1. AS
    Alan S. Perelson

    Los Alamos National Laboratory, United States

    4 publications · 307 citations

    4

    h-index

  2. KJ
    Kevin Jon Williams

    Thomas Jefferson University, United States

    3 publications · 415 citations

    3

    h-index

  3. FY
    Fangfei Yin

    Renji Hospital, China

    2 publications · 244 citations

    2

    h-index

  4. XZ
    Xiaolei Zuo

    Shanghai Institute of Applied Physics, China

    2 publications · 244 citations

    2

    h-index

  5. LW
    Lihua Wang

    Chinese Academy of Sciences, China

    2 publications · 244 citations

    2

    h-index

1–5 of 389

Institutions

192

  1. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    15 publications

    417 citations

  2. Chinese Academy of Sciences

    Beijing, China

    4 h-index

    11 publications

    1K citations

  3. Los Alamos National Laboratory

    Los Alamos, United States

    3 h-index

    3 publications

    262 citations

  4. Northwestern University

    Evanston, United States

    3 h-index

    9 publications

    163 citations

  5. McGill University

    Montreal, Canada

    3 h-index

    6 publications

    213 citations

  6. Thomas Jefferson University

    Philadelphia, United States

    3 h-index

    7 publications

    767 citations

  7. University of California, Berkeley

    Berkeley, United States

    3 h-index

    9 publications

    552 citations

  8. Brown University

    Providence, United States

    3 h-index

    3 publications

    262 citations

1–8 of 192

Venues

  1. Journal of the American Chemical Society

    JACS · 7 publications · 1.1K citations

    7

    h-index

  2. Biophysical Journal

    5 publications · 287 citations

    5

    h-index

  3. Mathematical Biosciences

    4 publications · 282 citations

    4

    h-index

  4. Journal of Biological Chemistry

    JBC · 3 publications · 183 citations

    3

    h-index

  5. Chemical Science

    3 publications · 88 citations

    3

    h-index

1–5