Concepedia

Library Diversity Optimization

Library Diversity Optimization is a methodological framework in antibody library construction and display technologies that systematically enhances the representational breadth and quality of antibody variants within a library to maximize the likelihood of identifying high-affinity binders during selection processes.

17

Publications

591

Citations

82

Authors

33

Institutions

Publications per year

2017–2026

4

Parents

Publications

17

Optimization of primer sequences for mouse scFv repertoire display library construction

Hong Zhou, Robert J. Fisher, Takis S. Papas · Nucleic Acids Research · 1994 · 79 citations · Full text

, , +11

Construction of a Large Synthetic Human scFv Library with Six Diversified CDRs and High Functional Diversity

Hye Young Yang, Kyung Jae Kang, Julia Eunyoung Chung et al. · Molecules and Cells · 2009 · 77 citations · Full text

, , +17

Optimal trade-off control in machine learning–based library design, with application to adeno-associated virus (AAV) for gene therapy

Danqing Zhu, David H. Brookes, Akosua Busia et al. · Science Advances · 2024 · 48 citations · Full text

, , +17

Improved genome sequencing using an engineered transposase

Amirali Kia, Christian Johannes Gloeckner, Trina Osothprarop et al. · BMC Biotechnology · 2017 · 47 citations · Full text

, , +16

Generation and analyses of human synthetic antibody libraries and their application for protein microarrays

Anna Säll, Maria Walle, Christer Wingren et al. · Protein Engineering Design and Selection · 2016 · 44 citations · Full text

, , +17

1–5 of 17

Authors

82

  1. DS
    David Shin

    University of California, San Francisco, United States

    2 publications · 65 citations

    2

    h-index

  2. DH
    David H. Brookes

    University of California, Berkeley, United States

    2 publications · 65 citations

    2

    h-index

  3. DZ
    Danqing Zhu

    Stanford University, United States

    2 publications · 65 citations

    2

    h-index

  4. MW
    Marvin Waldman

    Simulations Plus (United States), United States

    2 publications · 48 citations

    2

    h-index

  5. JL
    Jennifer Listgarten

    Microsoft (United States), United States

    2 publications · 65 citations

    2

    h-index

1–5 of 82

Institutions

33

  1. Simulations Plus (United States)

    Lancaster, United States

    2 h-index

    6 publications

    144 citations

  2. University of Oxford

    Oxford, United Kingdom

    2 h-index

    4 publications

    122 citations

  3. University of California, Berkeley

    Berkeley, United States

    2 h-index

    16 publications

    551 citations

  4. University of California, San Francisco

    San Francisco, United States

    2 h-index

    9 publications

    308 citations

  5. Broad Center

    Los Angeles, United States

    2 h-index

    6 publications

    195 citations

  6. QB3

    San Francisco, United States

    2 h-index

    4 publications

    130 citations

  7. Neurological Surgery

    Rockville Centre, United States

    2 h-index

    4 publications

    130 citations

  8. Innovative Genomics Institute

    Berkeley, United States

    2 h-index

    2 publications

    65 citations

1–8 of 33

Venues

  1. 3

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 2 publications · 56 citations

    2

    h-index

  3. Journal of Molecular Graphics and Modelling

    2 publications · 48 citations

    2

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 43 citations

    2

    h-index

  5. Tetrahedron Letters

    1 publications · 33 citations

    1

    h-index

1–5