Concepedia

Leucine Zipper Dimerization

Leucine Zipper Dimerization is a protein dimerization mechanism characterized by the association of two alpha-helical regions containing regularly spaced leucine residues that interlock in a coiled-coil structure, thereby facilitating sequence-specific DNA binding or protein-protein interactions in transcription factors.

336

Publications

36.1K

Citations

1.3K

Authors

403

Institutions

Publications per year

2017–2026

19

Parents

Publications

336

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

William Landschulz, Peter F. Johnson, Steven L. McKnight · Science · 1988 · 3.5K citations

, , +16

A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants

Pehr B. Harbury, Tao Zhang, Peter S. Kim et al. · Science · 1993 · 1.5K citations

, , +15

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

Tom Curran · Proceedings of the National Academy of Sciences · 1991 · 1.3K citations

, , +14

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.

Tsonwin Hai, F Liu, W. J. Coukos et al. · Genes & Development · 1989 · 1.1K citations · Full text

, , +12

The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex

Thomas E. Ellenberger, Christopher J. Brandl, Kevin Struhl et al. · Cell · 1992 · 985 citations

, , +17

1–5 of 336

Authors

1.3K

  1. KS
    Kevin Struhl

    Harvard University, United States

    7 publications · 1.2K citations

    7

    h-index

  2. CV
    Charles Vinson

    National Institutes of Health, United States

    7 publications · 1K citations

    7

    h-index

  3. PS
    Peter S. Kim

    Whitehead Institute for Biomedical Research, United States

    6 publications · 3.1K citations

    6

    h-index

  4. TC
    Tom Curran

    La Roche College, United States

    6 publications · 2.3K citations

    6

    h-index

  5. DH
    Daniel H. González

    Universidad Nacional del Litoral, Argentina

    6 publications · 281 citations

    6

    h-index

1–5 of 1.3K

Institutions

403

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    35 publications

    7.2K citations

  2. Harvard University

    Cambridge, United States

    15 h-index

    45 publications

    11.7K citations

  3. National Institutes of Health

    Bethesda, United States

    12 h-index

    47 publications

    6.1K citations

  4. Massachusetts Institute of Technology

    Cambridge, United States

    10 h-index

    31 publications

    6.4K citations

  5. National Cancer Institute

    Bethesda, United States

    9 h-index

    35 publications

    6.4K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    32 publications

    953 citations

  7. Yale University

    New Haven, United States

    7 h-index

    22 publications

    1.8K citations

  8. New York University

    New York, United States

    7 h-index

    19 publications

    5.1K citations

1–8 of 403

Venues

  1. Journal of Biological Chemistry

    JBC · 43 publications · 3K citations

    32

    h-index

  2. Molecular and Cellular Biology

    MCB · 34 publications · 2.8K citations

    28

    h-index

  3. Biochemistry

    23 publications · 1.1K citations

    21

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 23 publications · 3.3K citations

    20

    h-index

  5. Journal of Virology

    JVI · 16 publications · 768 citations

    16

    h-index

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