Concepedia

Left-right Axis Establishment

Left-Right Axis Establishment is a developmental biological process that determines the asymmetric positioning of internal organs along the left-right plane during embryogenesis, distinguished from other axial specification events by its reliance on cilia-driven fluid flow and asymmetric gene expression initiated at the primitive streak.

223

Publications

23.9K

Citations

908

Authors

332

Institutions

Publications per year

2017–2026

22

Variants

Left-right Axis Specification

Parents

Publications

223

Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein

Shigenori Nonaka, Yosuke Tanaka, Yasushi Okada et al. · Cell · 1998 · 1.6K citations · Full text

, , +12

Determination of left–right patterning of the mouse embryo by artificial nodal flow

Shigenori Nonaka, Hidetaka Shiratori, Yukio Saijoh et al. · Nature · 2002 · 688 citations

, , +16

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

Edgar A. Otto, Bernhard Schermer, Tomoko Obara et al. · Nature Genetics · 2003 · 642 citations · Full text

, , +14

Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut

Jeffrey J. Essner, Jeffrey D. Amack, Molly K. Nyholm et al. · Development · 2005 · 642 citations

, , +16

Pitx2 determines left–right asymmetry of internal organs in vertebrates

Aimee K. Ryan, Bruce Blumberg, Concepción Rodrı́guez-Esteban et al. · Nature · 1998 · 531 citations

, , +16

1–5 of 223

Authors

908

  1. HH
    Hiroshi Hamada

    The University of Osaka, Japan

    14 publications · 2.3K citations

    14

    h-index

  2. HJ
    H. Joseph Yost

    University of Utah, United States

    14 publications · 1.8K citations

    14

    h-index

  3. ML
    Michael Levin

    Tufts University, United States

    9 publications · 942 citations

    9

    h-index

  4. MB
    Martin Blum

    University of Hohenheim, Germany

    8 publications · 1.3K citations

    8

    h-index

  5. RD
    Rebecca D. Burdine

    Princeton University, United States

    7 publications · 983 citations

    7

    h-index

1–5 of 908

Institutions

332

  1. Harvard University

    Cambridge, United States

    14 h-index

    30 publications

    5.6K citations

  2. The University of Osaka

    Osaka, Japan

    13 h-index

    59 publications

    9.7K citations

  3. The University of Tokyo

    Tokyo, Japan

    12 h-index

    67 publications

    18K citations

  4. University of Utah

    Salt Lake City, United States

    11 h-index

    25 publications

    4.7K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    38 publications

    4.3K citations

  6. Japan Science and Technology Agency

    Tokyo, Japan

    8 h-index

    30 publications

    6.9K citations

  7. National Institutes of Health

    Bethesda, United States

    7 h-index

    18 publications

    2.6K citations

  8. RIKEN Center for Brain Science

    Wako, Japan

    6 h-index

    23 publications

    2.2K citations

1–8 of 332

Venues

  1. Development

    34 publications · 3.6K citations

    28

    h-index

  2. Developmental Biology

    25 publications · 2K citations

    20

    h-index

  3. Developmental Dynamics

    9 publications · 298 citations

    9

    h-index

  4. Genes & Development

    7 publications · 1.3K citations

    7

    h-index

  5. Nature

    6 publications · 2K citations

    6

    h-index

1–5