Concepedia

Lead-like Space

Lead-Like Space is a region within the broader chemical space composed of molecules that exhibit physicochemical properties conducive to optimization into drug leads, distinguished from other regions by its adherence to criteria such as reduced molecular weight and lipophilicity compared to typical drug-like space to enhance tractability in hit-to-lead development.

12

Publications

1.4K

Citations

59

Authors

40

Institutions

Publications per year

2017–2026

3

Parents

Publications

12

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

Ruth Brenk, Alessandro Schipani, Daniel James et al. · ChemMedChem · 2007 · 694 citations · Full text

, , +16

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

Melissa L. Boby, Neşe Kurt Yılmaz, Daniel Zaidmann et al. · Science · 2023 · 175 citations · Full text

, , +17

Lead-like, drug-like or “Pub-like”: how different are they?

Tudor I. Oprea, Tharun Kumar Allu, Dan C. Fara et al. · Journal of Computer-Aided Molecular Design · 2007 · 115 citations · Full text

, , +4

Molecular Filters in Medicinal Chemistry

Sebastjan Kralj, Marko Jukič, Urban Bren · Encyclopedia · 2023 · 88 citations · Full text

, , +16

Is chemical synthetic accessibility computationally predictable for drug and lead-like molecules? A comparative assessment between medicinal and computational chemists

Pascal Bonnet · European Journal of Medicinal Chemistry · 2012 · 70 citations

, , +17

1–5 of 12

Authors

59

  1. RB
    Ruth Brenk

    University of Dundee, United Kingdom

    2 publications · 717 citations

    2

    h-index

  2. IZ
    Ivy Zhang

    Memorial Sloan Kettering Cancer Center, United States

    1 publications · 175 citations

    1

    h-index

  3. NZ
    Nicole Zitzmann

    University of Oxford, United Kingdom

    1 publications · 175 citations

    1

    h-index

  4. DZ
    Daniel Zaidmann

    Weizmann Institute of Science, Israel

    1 publications · 175 citations

    1

    h-index

  5. TK
    Tharun Kumar Allu

    University of New Mexico, United States

    1 publications · 115 citations

    1

    h-index

1–5 of 59

Institutions

40

  1. University of Dundee

    Dundee, United Kingdom

    2 h-index

    10 publications

    4.9K citations

  2. University of Bern

    Bern, Switzerland

    1 h-index

    3 publications

    81 citations

  3. University of Oxford

    Oxford, United Kingdom

    1 h-index

    1 publications

    175 citations

  4. Drug Discovery Laboratory (Norway)

    Oslo, Norway

    1 h-index

    3 publications

    69 citations

  5. NBE Therapeutics (Switzerland)

    Basel, Switzerland

    1 h-index

    1 publications

    27 citations

  6. University of Primorska

    Koper, Slovenia

    1 h-index

    2 publications

    176 citations

  7. Memorial Sloan Kettering Cancer Center

    New York, United States

    1 h-index

    2 publications

    350 citations

  8. Stockholm University

    Stockholm, Sweden

    1 h-index

    2 publications

    54 citations

1–8 of 40

Venues

  1. Journal of Chemical Information and Modeling

    JCIM · 3 publications · 110 citations

    3

    h-index

  2. Journal of Computer-Aided Molecular Design

    2 publications · 142 citations

    2

    h-index

  3. European Journal of Medicinal Chemistry

    1 publications · 70 citations

    1

    h-index

  4. Encyclopedia

    1 publications · 88 citations

    1

    h-index

  5. Chemical Communications

    ChemComm · 1 publications · 58 citations

    1

    h-index

1–5