Concepedia

Lagging Strand Assembly

Lagging Strand Assembly is a molecular biosynthesis process in DNA replication wherein discontinuous synthesis of the nascent DNA strand occurs through the sequential addition of Okazaki fragments, distinguished from continuous leading strand synthesis by its reliance on repeated initiation events mediated by primase and DNA polymerase activities.

23

Publications

2.8K

Citations

84

Authors

37

Institutions

Publications per year

2017–2026

3

Parents

Publications

23

Sequential initiation of lagging and leading strand synthesis by two different polymerase complexes at the SV40 DNA replication origin

Toshiki Tsurimoto, Thomas Melendy, Bruce Stillman · Nature · 1990 · 428 citations

, , +17

Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA

Gregory Prelich, Bruce Stillman · Cell · 1988 · 393 citations

, , +13

Intrinsic coupling of lagging-strand synthesis to chromatin assembly

Duncan J. Smith, Iestyn Whitehouse · Nature · 2012 · 302 citations

, , +14

A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

Robert E. Johnson, Roland Klassen, Louise Prakash et al. · Molecular Cell · 2015 · 190 citations · Full text

, , +16

Devoted to the lagging strand—the χ subunit of DNA polymerase III holoenzyme contacts SSB to promote processive elongation and sliding clamp assembly

Zvi Kelman · The EMBO Journal · 1998 · 190 citations · Full text

, , +14

1–5 of 23

Authors

84

  1. BS
    Bruce Stillman

    Cold Spring Harbor Laboratory, United States

    4 publications · 1K citations

    4

    h-index

  2. CC
    Charles C. Richardson

    Harvard University, United States

    2 publications · 206 citations

    2

    h-index

  3. TT
    Toshiki Tsurimoto

    Kyushu University, Japan

    2 publications · 510 citations

    2

    h-index

  4. SJ
    Stephen J. Benkovic

    Pennsylvania State University, United States

    2 publications · 74 citations

    2

    h-index

  5. MO
    Mike O’Donnell

    Howard Hughes Medical Institute, United States

    2 publications · 259 citations

    2

    h-index

1–5 of 84

Institutions

37

  1. Cold Spring Harbor Laboratory

    Cold Spring Harbor, United States

    4 h-index

    8 publications

    2.4K citations

  2. Rockefeller University

    New York, United States

    2 h-index

    7 publications

    1K citations

  3. Harvard University

    Cambridge, United States

    2 h-index

    7 publications

    835 citations

  4. Pennsylvania State University

    State College, United States

    2 h-index

    11 publications

    425 citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    4 publications

    518 citations

  6. Zhejiang University

    Hangzhou, China

    1 h-index

    2 publications

    44 citations

  7. Michigan Medicine

    Ann Arbor, United States

    1 h-index

    1 publications

    81 citations

  8. University of Pennsylvania

    Philadelphia, United States

    1 h-index

    5 publications

    245 citations

1–8 of 37

Venues

  1. Nature

    3 publications · 871 citations

    3

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 231 citations

    3

    h-index

  3. Molecular Cell

    3 publications · 328 citations

    3

    h-index

  4. Journal of Molecular Biology

    JMB · 2 publications · 93 citations

    2

    h-index

  5. Molecular and Cellular Biology

    MCB · 2 publications · 146 citations

    2

    h-index

1–5