Concepedia

Ku70-ku80 Complex

The Ku70-Ku80 Complex is a heterodimeric protein complex belonging to the nonhomologous end-joining pathway of DNA double-strand break repair, distinguished by its ability to recognize and bind to DNA ends with high affinity, thereby serving as a critical scaffold for the recruitment of downstream repair factors including DNA-PKcs, XRCC4, and DNA ligase IV, and playing an essential role in V(D)J recombination during immune system development.

216

Publications

19.6K

Citations

1.2K

Authors

399

Institutions

Publications per year

2017–2026

37

Variants

Ku70/80 ComplexKu70/ku80 Complex

Parents

Publications

216

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Tanya Gottlieb, Stephen P. Jackson · Cell · 1993 · 1.2K citations

, , +14

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

John R. Walker, Richard A. Corpina, Jonathan M. Goldberg · Nature · 2001 · 1.2K citations

, , +14

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

Simon J. Boulton · Nucleic Acids Research · 1996 · 482 citations · Full text

, , +17

Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

Yansong Gu, Katherine J. Seidl, Gary Rathbun et al. · Immunity · 1997 · 458 citations · Full text

, , +17

Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

Pierre‐Olivier Mari, Bogdan I. Florea, Stephan P. Persengiev et al. · Proceedings of the National Academy of Sciences · 2006 · 400 citations · Full text

, , +17

1–5 of 216

Authors

1.2K

  1. DJ
    David J. Chen

    The University of Texas Southwestern Medical Center, United States

    9 publications · 1.1K citations

    9

    h-index

  2. MK
    Manabu Koike

    National Institutes for Quantum Science and Technology, Japan

    9 publications · 288 citations

    9

    h-index

  3. SP
    Stephen P. Jackson

    The Gurdon Institute, United Kingdom

    7 publications · 1.9K citations

    7

    h-index

  4. SP
    Susan P. Lees‐Miller

    University of Calgary, Canada

    7 publications · 977 citations

    7

    h-index

  5. AK
    Aki Koike

    National Institutes for Quantum Science and Technology, Japan

    7 publications · 183 citations

    7

    h-index

1–5 of 1.2K

Institutions

399

  1. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    71 publications

    6K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    11 h-index

    40 publications

    3.2K citations

  3. University of Calgary

    Calgary, Canada

    10 h-index

    32 publications

    4.1K citations

  4. National Institutes of Health

    Bethesda, United States

    8 h-index

    16 publications

    2.7K citations

  5. Lawrence Berkeley National Laboratory

    Berkeley, United States

    7 h-index

    22 publications

    3.5K citations

  6. Inserm

    Paris, France

    7 h-index

    27 publications

    937 citations

  7. The Gurdon Institute

    Cambridge, United Kingdom

    6 h-index

    14 publications

    2.1K citations

  8. National Cancer Institute

    Bethesda, United States

    6 h-index

    23 publications

    4.1K citations

1–8 of 399

Venues

  1. Journal of Biological Chemistry

    JBC · 19 publications · 2.1K citations

    19

    h-index

  2. Nucleic Acids Research

    16 publications · 1.8K citations

    16

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 15 publications · 2.6K citations

    15

    h-index

  4. Molecular and Cellular Biology

    MCB · 6 publications · 466 citations

    6

    h-index

  5. Journal of Cell Science

    4 publications · 141 citations

    4

    h-index

1–5