JAK2 V617F Mutation is a somatic gain-of-function point mutation in the Janus kinase 2 (JAK2) gene, characterized by a valine-to-phenylalanine substitution at position 617, that constitutively activates the JAK-STAT signaling pathway and is predominantly associated with the pathogenesis of classical BCR-ABL1–negative myeloproliferative neoplasms.
1K
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Publications per year
2017–2026
247
Variants
Jak2 V617f
Parents
Publications
1K
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
Chloé James, Valérie Ugo, Jean‐Pierre Le Couedic et al. · Nature · 2005 · 3.5K citations
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
E. Joanna Baxter, Linda M. Scott, Peter J. Campbell et al. · The Lancet · 2005 · 3.4K citations
Life Sciences, Genetics, Hematology +14
MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia
Yana Pikman, Benjamin H. Lee, Thomas Mercher et al. · PLoS Medicine · 2006 · 1.4K citations · Full text
Life Sciences, Genetics, Hematology +14
<i>JAK2</i> Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis
Linda M. Scott, Wei Tong, Ross L. Levine et al. · New England Journal of Medicine · 2007 · 1.2K citations · Full text
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
E. Joanna Baxter, Linda M. Scott, Peter J. Campbell et al. · The Lancet · 2005 · 1.1K citations
Life Sciences, Genetics, Hematology +14
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Inserm
Paris, France
45 h-index
512 publications
83.7K citations
Mayo Clinic in Arizona
Scottsdale, United States
38 h-index
246 publications
49.1K citations
Harvard University
Cambridge, United States
37 h-index
185 publications
68.4K citations
University of Florence
Florence, Italy
36 h-index
196 publications
30.4K citations
Mayo Clinic
Rochester, United States
35 h-index
211 publications
25.4K citations
Istituti di Ricovero e Cura a Carattere Scientifico
Rome, Italy
35 h-index
203 publications
33.3K citations
Dana-Farber Cancer Institute
Boston, United States
32 h-index
185 publications
57.1K citations
University of Cambridge
Cambridge, United Kingdom
32 h-index
190 publications
59.7K citations
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Venues
- Blood
139 publications · 19.6K citations
74
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- Leukemia
43 publications · 6.4K citations
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- Haematologica
45 publications · 2.7K citations
31
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- British Journal of Haematology
BJH · 46 publications · 3K citations
29
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- American Journal of Hematology
AJH · 34 publications · 1.6K citations
23
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