Concepedia

Ionophoric Uncoupling

Ionophoric Uncoupling is a biochemical mechanism in bioenergetic coupling wherein lipid-soluble ion carriers disrupt mitochondrial proton gradients by facilitating the passive transport of ions across the inner mitochondrial membrane, thereby uncoupling oxidative phosphorylation from ATP synthesis.

14

Publications

727

Citations

40

Authors

24

Institutions

Publications per year

2017–2026

1

Parents

Publications

14

Prodigiosins uncouple lysosomal vacuolar-type ATPase through promotion of H+/Cl− symport

Shoji Ohkuma, Tomohiko Sato, Masayuki Okamoto et al. · Biochemical Journal · 1998 · 134 citations · Full text

, , +13

Uncoupling proteins: current status and therapeutic prospects

Jan Nedergaard, Daniel Ricquier, Leslie P. Kozak · EMBO Reports · 2005 · 132 citations · Full text

, , +5

Ionophoric effects of the antitubercular drug bedaquiline

Kiel Hards, Duncan G. G. McMillan, Lici A. Schurig-Briccio et al. · Proceedings of the National Academy of Sciences · 2018 · 99 citations · Full text

, , +16

Mechanism of uncoupling in mitochondria: uncouplers as ionophores for cycling cations and protons.

Ralph J. Kessler, C.A. Tyson, D E Green · Proceedings of the National Academy of Sciences · 1976 · 78 citations · Full text

, , +16

Unmasking the mitochondrial KH exchanger: Swelling-induced K+-loss

Keith Garlid · Biochemical and Biophysical Research Communications · 1978 · 55 citations

, , +14

1–5 of 14

Authors

40

  1. RJ
    Ralph J. Kessler

    University of California San Diego, United States

    3 publications · 130 citations

    3

    h-index

  2. DE
    D E Green

    University of Wisconsin–Madison, United States

    2 publications · 89 citations

    2

    h-index

  3. GA
    George A. Blondin

    University of Wisconsin–Madison, United States

    2 publications · 52 citations

    2

    h-index

  4. IE
    I. Engström

    Uppsala University Hospital, Sweden

    2 publications · 29 citations

    2

    h-index

  5. CT
    C.A. Tyson

    SRI International, United States

    2 publications · 119 citations

    2

    h-index

1–5 of 40

Institutions

24

  1. Uppsala University Hospital

    Uppsala, Sweden

    2 h-index

    6 publications

    87 citations

  2. University of Illinois Urbana-Champaign

    Urbana, United States

    2 h-index

    3 publications

    235 citations

  3. University of Toledo Medical Center

    Toledo, United States

    2 h-index

    2 publications

    99 citations

  4. University of Wisconsin–Madison

    Madison, United States

    2 h-index

    7 publications

    278 citations

  5. Yale University

    New Haven, United States

    1 h-index

    1 publications

    134 citations

  6. University of Auckland

    Auckland, New Zealand

    1 h-index

    1 publications

    99 citations

  7. Wenner-Gren Foundations

    Stockholm, Sweden

    1 h-index

    1 publications

    132 citations

  8. Pennington Biomedical Research Center

    Baton Rouge, United States

    1 h-index

    1 publications

    132 citations

1–8 of 24

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 229 citations

    4

    h-index

  2. Biochemical and Biophysical Research Communications

    BBRC · 2 publications · 99 citations

    2

    h-index

  3. 2

    h-index

  4. The Journal of Antibiotics

    1 publications · 21 citations

    1

    h-index

  5. PLANT PHYSIOLOGY

    1 publications · 37 citations

    1

    h-index

1–5