Concepedia

Interface Structural Conservation

Interface Structural Conservation is a structural biology concept that refers to the preservation of three-dimensional arrangement and physicochemical properties at protein-protein interaction interfaces across evolutionary divergences, indicating functional and mechanistic constraints.

20

Publications

1.5K

Citations

95

Authors

38

Institutions

Publications per year

2017–2026

4

Parents

Publications

20

A Simple Definition of Structural Regions in Proteins and Its Use in Analyzing Interface Evolution

Emmanuel D. Levy · Journal of Molecular Biology · 2010 · 269 citations

, , +16

Structural conservation of druggable hot spots in protein–protein interfaces

Dima Kozakov, David R. Hall, Gwo‐Yu Chuang et al. · Proceedings of the National Academy of Sciences · 2011 · 246 citations · Full text

, , +17

Structural Conservation of the Pores of Calcium-activated and Voltage-gated Potassium Channels Determined by a Sea Anemone Toxin

Heiko Rauer, Michael W. Pennington, Michael D. Cahalan et al. · Journal of Biological Chemistry · 1999 · 132 citations · Full text

, , +17

Identification of protein oligomerization states by analysis of interface conservation

Adrian H. Elcock, J. Andrew McCammon · Proceedings of the National Academy of Sciences · 2001 · 110 citations · Full text

, , +16

Conserved residue clusters at protein-protein interfaces and their use in binding site identification

Mainak Guharoy, Pinak Chakrabarti · BMC Bioinformatics · 2010 · 102 citations · Full text

, , +17

1–5 of 20

Authors

95

  1. PC
    Pinak Chakrabarti

    Bose Institute, India

    1 publications · 102 citations

    1

    h-index

  2. LH
    Leonhard Heizinger

    University of Regensburg, Germany

    1 publications · 30 citations

    1

    h-index

  3. ON
    Osman N. Yoğurtçu

    Center for Biologics Evaluation and Research, United States

    1 publications · 75 citations

    1

    h-index

  4. MG
    Mainak Guharoy

    Vrije Universiteit Brussel, Belgium

    1 publications · 102 citations

    1

    h-index

  5. AH
    Adrian H. Elcock

    University of Iowa, United States

    1 publications · 110 citations

    1

    h-index

1–5 of 95

Institutions

38

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    3 publications

    289 citations

  2. University of California San Diego

    San Diego, United States

    2 h-index

    12 publications

    828 citations

  3. Bose Institute

    Kolkata, India

    1 h-index

    2 publications

    204 citations

  4. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    1 h-index

    1 publications

    269 citations

  5. Novo Nordisk Foundation

    Copenhagen, Denmark

    1 h-index

    6 publications

    90 citations

  6. Johns Hopkins University

    Baltimore, United States

    1 h-index

    5 publications

    290 citations

  7. University of Edinburgh

    Edinburgh, United Kingdom

    1 h-index

    3 publications

    45 citations

  8. Science Applications International Corporation (United States)

    McLean, United States

    1 h-index

    1 publications

    75 citations

1–8 of 38

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 524 citations

    6

    h-index

  2. Journal of Molecular Biology

    JMB · 2 publications · 338 citations

    2

    h-index

  3. Journal of Biological Chemistry

    JBC · 2 publications · 181 citations

    2

    h-index

  4. Journal of Structural Biology

    1 publications · 22 citations

    1

    h-index

  5. EMBO Reports

    1 publications · 15 citations

    1

    h-index

1–5