Concepedia

Integrin-mediated Mechanosensing

Integrin-Mediated Mechanosensing is a cellular mechanotransduction process in which transmembrane integrin receptors detect and convert extracellular mechanical cues into intracellular biochemical signals through force-dependent conformational changes and adhesion complex remodeling.

312

Publications

28.3K

Citations

1.7K

Authors

512

Institutions

Publications per year

2017–2026

95

Parents

Publications

312

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

Andrew J. Maniotis, Christopher S. Chen, Donald E. Ingber · Proceedings of the National Academy of Sciences · 1997 · 1.6K citations

, , +17

Demonstration of catch bonds between an integrin and its ligand

Fang Kong, Andrés J. Garcı́a, A. Paul Mould et al. · The Journal of Cell Biology · 2009 · 708 citations · Full text

, , +17

Activation of integrins in endothelial cells by fluid shear stress mediates Rho‐dependent cytoskeletal alignment

Miguel Á. del Pozo, Sanford J. Shattil, Shu Chien et al. · The EMBO Journal · 2001 · 568 citations · Full text

, , +16

Mechanotransduction in Response to Shear Stress

Kuang‐Den Chen, Yi‐Shuan Li, Michael Kim et al. · Journal of Biological Chemistry · 1999 · 562 citations · Full text

, , +17

Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels

Benjamin D. Matthews, Darryl R. Overby, Robert Mannix et al. · Journal of Cell Science · 2006 · 454 citations

, , +17

1–5 of 312

Authors

1.7K

  1. DE
    Donald E. Ingber

    Harvard University, United States

    9 publications · 3.3K citations

    9

    h-index

  2. GA
    Gerald A. Meininger

    University of Missouri, United States

    8 publications · 447 citations

    8

    h-index

  3. DM
    Donald M. Salter

    University of Edinburgh, United Kingdom

    8 publications · 666 citations

    8

    h-index

  4. MO
    M. O. Wright

    University of Edinburgh, United Kingdom

    7 publications · 733 citations

    7

    h-index

  5. DG
    Donald Gullberg

    University of Bergen, Norway

    6 publications · 625 citations

    6

    h-index

1–5 of 1.7K

Institutions

512

  1. Harvard University

    Cambridge, United States

    17 h-index

    73 publications

    15.8K citations

  2. Georgia Institute of Technology

    Atlanta, United States

    12 h-index

    33 publications

    4.4K citations

  3. University of California San Diego

    San Diego, United States

    11 h-index

    48 publications

    9.7K citations

  4. Boston Children's Hospital

    Boston, United States

    10 h-index

    41 publications

    10.8K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    46 publications

    2K citations

  6. University of California, San Francisco

    San Francisco, United States

    9 h-index

    42 publications

    4.5K citations

  7. University of Edinburgh

    Edinburgh, United Kingdom

    9 h-index

    38 publications

    3.9K citations

  8. University of Toronto

    Toronto, Canada

    8 h-index

    26 publications

    1.5K citations

1–8 of 512

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 4.1K citations

    12

    h-index

  2. Journal of Biological Chemistry

    JBC · 11 publications · 2K citations

    11

    h-index

  3. Nature Communications

    10 publications · 1K citations

    10

    h-index

  4. Biophysical Journal

    10 publications · 726 citations

    10

    h-index

  5. Journal of Biomechanics

    8 publications · 299 citations

    8

    h-index

1–5