Concepedia

Integrase-recombinase Engineering

Integrase-Recombinase Engineering is a methodological framework within molecular biology that involves the rational design and optimization of integrase and recombinase enzymes to achieve precise, efficient, and orthogonal DNA recombination at predetermined genomic sites.

22

Publications

1.1K

Citations

131

Authors

54

Institutions

Publications per year

2017–2026

8

Parents

Publications

22

Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

Smriti Pandey, Xin D. Gao, N Krasnow et al. · Nature Biomedical Engineering · 2024 · 161 citations · Full text

, , +15

Directed evolution of a recombinase for improved genomic integration at a native human sequence

C. R. Sclimenti · Nucleic Acids Research · 2001 · 113 citations · Full text

, , +17

A novel Bxb1 integrase RMCE system for high fidelity site‐specific integration of mAb expression cassette in CHO Cells

Mara C. Inniss, Kalpanie Bandara, Barbara Jusiak et al. · Biotechnology and Bioengineering · 2017 · 100 citations

, , +17

Implementation of stable and complex biological systems through recombinase-assisted genome engineering

Christine Nicole S. Santos, Drew D. Regitsky, Yasuo Yoshikuni · Nature Communications · 2013 · 93 citations · Full text

, , +14

Synthesis of programmable integrases

Russell M. Gordley, Charles A. Gersbach, Carlos F. Barbas · Proceedings of the National Academy of Sciences · 2009 · 91 citations · Full text

, , +17

1–5 of 22

Authors

131

  1. JM
    Jonathan M. Geisinger

    Stanford University, United States

    2 publications · 68 citations

    2

    h-index

  2. AP
    Alfonso P. Farruggio

    Stanford University, United States

    2 publications · 68 citations

    2

    h-index

  3. CL
    Christopher L. Chavez

    Stanford University, United States

    2 publications · 68 citations

    2

    h-index

  4. JR
    Jack R Bateman

    Harvard University, United States

    2 publications · 41 citations

    2

    h-index

  5. MK
    Marisa Karow

    Ludwig-Maximilians-Universität München, Germany

    2 publications · 68 citations

    2

    h-index

1–5 of 131

Institutions

54

  1. Stanford University

    Stanford, United States

    3 h-index

    19 publications

    735 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    9 publications

    336 citations

  3. Harvard University

    Cambridge, United States

    2 h-index

    11 publications

    1.5K citations

  4. University of Minnesota Medical Center

    Minneapolis, United States

    1 h-index

    4 publications

    644 citations

  5. National Aeronautics and Space Administration

    Washington, United States

    1 h-index

    1 publications

    34 citations

  6. Kyoto University

    Kyoto, Japan

    1 h-index

    1 publications

    27 citations

  7. Beth Israel Deaconess Medical Center

    Boston, United States

    1 h-index

    1 publications

    161 citations

  8. Chinese Academy of Sciences

    Beijing, China

    1 h-index

    4 publications

    296 citations

1–8 of 54

Venues

  1. Nucleic Acids Research

    3 publications · 175 citations

    3

    h-index

  2. ACS Synthetic Biology

    2 publications · 62 citations

    2

    h-index

  3. Genetics

    2 publications · 41 citations

    2

    h-index

  4. Biotechnology and Bioengineering

    2 publications · 129 citations

    2

    h-index

  5. Nature Communications

    2 publications · 124 citations

    2

    h-index

1–5