Concepedia

Insulator Function

Insulator Function is a genomic regulatory element that belongs to the class of cis-regulatory sequences and is distinguished by its ability to block enhancer-promoter interactions or shield genes from positional effects of neighboring chromatin domains, thereby maintaining independent transcriptional regulation.

206

Publications

16.9K

Citations

897

Authors

315

Institutions

Publications per year

2017–2026

31

Parents

Publications

206

Insulator dysfunction and oncogene activation in IDH mutant gliomas

William Flavahan, Yotam Drier, Brian B. Liau et al. · Nature · 2015 · 1.3K citations · Full text

, , +16

The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators

Adam C. Bell, Adam G. West, Gary Felsenfeld · Cell · 1999 · 1.1K citations · Full text

, , +15

CTCF physically links cohesin to chromatin

Eric D. Rubio, David J. Reiss, Piri Welcsh et al. · Proceedings of the National Academy of Sciences · 2008 · 505 citations · Full text

, , +17

Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive

Chandrasekhar Kanduri, Vinod Pant, Dmitri Loukinov et al. · Current Biology · 2000 · 446 citations · Full text

, , +14

Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

Michael J. Pikaart, Félix Recillas‐Targa, Gary Felsenfeld · Genes & Development · 1998 · 399 citations · Full text

, , +17

1–5 of 206

Authors

897

  1. PG
    Pavel Georgiev

    Institute of Gene Biology, Russia

    23 publications · 1.4K citations

    19

    h-index

  2. VG
    Victor G. Corces

    Johns Hopkins University, United States

    10 publications · 1.2K citations

    10

    h-index

  3. PG
    Pamela Geyer

    University of Iowa, United States

    10 publications · 628 citations

    10

    h-index

  4. OM
    Oksana Maksimenko

    Institute of Gene Biology, Russia

    9 publications · 618 citations

    9

    h-index

  5. LS
    L. S. Melnikova

    Institute of Gene Biology, Russia

    8 publications · 297 citations

    8

    h-index

1–5 of 897

Institutions

315

  1. Institute of Gene Biology

    Moscow, Russia

    20 h-index

    109 publications

    7.3K citations

  2. National Institutes of Health

    Bethesda, United States

    16 h-index

    57 publications

    11.4K citations

  3. University of Iowa

    Iowa City, United States

    12 h-index

    43 publications

    2.7K citations

  4. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    10 h-index

    38 publications

    8.8K citations

  5. Emory University

    Atlanta, United States

    9 h-index

    44 publications

    5.7K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    31 publications

    2.7K citations

  7. Princeton University

    Princeton, United States

    7 h-index

    13 publications

    697 citations

  8. Johns Hopkins University

    Baltimore, United States

    7 h-index

    15 publications

    1.6K citations

1–8 of 315

Venues

  1. Molecular and Cellular Biology

    MCB · 19 publications · 1.5K citations

    18

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 1.9K citations

    12

    h-index

  3. Genetics

    12 publications · 609 citations

    12

    h-index

  4. Nucleic Acids Research

    11 publications · 576 citations

    11

    h-index

  5. PLoS ONE

    10 publications · 482 citations

    10

    h-index

1–5