Concepedia

Induced-fit Recognition

Induced-Fit Recognition is a molecular binding mechanism, distinguished from lock-and-key models by its reliance on conformational changes in the receptor or ligand upon interaction, enabling selective recognition of nucleic acid structures or allosteric regulators through dynamic structural adaptation.

40

Publications

3K

Citations

229

Authors

86

Institutions

Publications per year

2017–2026

2

Parents

Publications

40

Induced fit in synthetic receptors: nucleotide base recognition by a molecular hinge

Andrew D. Hamilton, Donna Van Engen · Journal of the American Chemical Society · 1987 · 250 citations

, , +15

Selective inhibitors of the FK506-binding protein 51 by induced fit

S. Gaali, Alexander Kirschner, Serena Cuboni et al. · Nature Chemical Biology · 2014 · 244 citations

, , +13

Fly-Casting in Protein−DNA Binding:  Frustration between Protein Folding and Electrostatics Facilitates Target Recognition

Yaakov Levy, José N. Onuchic, Peter G. Wolynes · Journal of the American Chemical Society · 2007 · 221 citations

, , +17

Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity

Chen Davidovich, Anat Bashan, T. Auerbach-Nevo et al. · Proceedings of the National Academy of Sciences · 2007 · 196 citations

, , +15

Large‐scale induced fit recognition of an m7GpppG cap analogue by the human nuclear cap‐binding complex

Catherine Mazza · The EMBO Journal · 2002 · 192 citations · Full text

, , +12

1–5 of 40

Authors

229

  1. JA
    John A. Parkinson

    University of Strathclyde, United Kingdom

    2 publications · 253 citations

    2

    h-index

  2. WD
    W. David Wilson

    Georgia State University, United States

    2 publications · 78 citations

    2

    h-index

  3. PJ
    Peter J. Sadler

    University of Warwick, United Kingdom

    2 publications · 253 citations

    2

    h-index

  4. RO
    Robert O. Gould

    University of Edinburgh, United Kingdom

    2 publications · 253 citations

    2

    h-index

  5. SP
    Simon Parsons

    University of Edinburgh, United Kingdom

    2 publications · 253 citations

    2

    h-index

1–5 of 229

Institutions

86

  1. Weizmann Institute of Science

    Rehovot, Israel

    3 h-index

    9 publications

    1.7K citations

  2. European Molecular Biology Laboratory

    Grenoble, France

    2 h-index

    3 publications

    421 citations

  3. Georgia State University

    Atlanta, United States

    2 h-index

    13 publications

    582 citations

  4. Shanghai Jiao Tong University

    Shanghai, China

    2 h-index

    13 publications

    397 citations

  5. European Molecular Biology Laboratory

    Heidelberg, Germany

    2 h-index

    3 publications

    448 citations

  6. University of Edinburgh

    Edinburgh, United Kingdom

    2 h-index

    20 publications

    2.5K citations

  7. Max Planck Institute of Biochemistry

    Martinsried, Germany

    2 h-index

    3 publications

    266 citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    8 publications

    388 citations

1–8 of 86

Venues

  1. Chemistry - A European Journal

    4 publications · 177 citations

    4

    h-index

  2. Biochemistry

    4 publications · 126 citations

    4

    h-index

  3. Journal of the American Chemical Society

    JACS · 4 publications · 725 citations

    4

    h-index

  4. Nucleic Acids Research

    2 publications · 118 citations

    2

    h-index

  5. Journal of Molecular Biology

    JMB · 2 publications · 164 citations

    2

    h-index

1–5