Concepedia

Indirect Response Modeling

Indirect Response Modeling is a class of pharmacodynamic modeling approaches in pharmacokinetic–pharmacodynamic analysis that characterize drug effects as indirect modulation (stimulation or inhibition) of the production or loss processes of a physiological response variable, thereby accounting for delayed and hysteretic relationships between drug concentration and observed effect.

73

Publications

7.2K

Citations

208

Authors

111

Institutions

Publications per year

2017–2026

9

Parents

Children

Publications

73

Advantages of Monte Carlo Confidence Intervals for Indirect Effects

Kristopher J. Preacher, James P. Selig · Communication Methods and Measures · 2012 · 1.8K citations

, , +13

A Simulation Study of Mediated Effect Measures

David P. MacKinnon, Ghulam Warsi, James H. Dwyer · Multivariate Behavioral Research · 1995 · 1.7K citations · Full text

, , +16

Comparison of four basic models of indirect pharmacodynamic responses

Natalie Dayneka, Varun Garg, William J. Jusko · Journal of Pharmacokinetics and Biopharmaceutics · 1993 · 811 citations

, , +14

Physiologic indirect response models characterize diverse types of pharmacodynamic effects

William J. Jusko, Hui C. Ko · Clinical Pharmacology & Therapeutics · 1994 · 357 citations

, , +16

Regression of calculated variables in the presence of shared measurement error

Howard H. Stratton, Paul J. Feustel, J.C. Newell · Journal of Applied Physiology · 1987 · 160 citations

, , +12

1–5 of 73

Authors

208

  1. WJ
    William J. Jusko

    University at Buffalo, State University of New York, United States

    18 publications · 1.7K citations

    14

    h-index

  2. WK
    Wojciech Krzyżański

    University at Buffalo, State University of New York, United States

    12 publications · 441 citations

    11

    h-index

  3. HZ
    Honghui Zhou

    Janssen (United States), United States

    5 publications · 118 citations

    5

    h-index

  4. CH
    Chuanpu Hu

    Janssen (United States), United States

    5 publications · 118 citations

    5

    h-index

  5. AS
    Amarnath Sharma

    Pfizer (United States), United States

    3 publications · 270 citations

    3

    h-index

1–5 of 208

Institutions

111

  1. University at Buffalo, State University of New York

    Buffalo, United States

    20 h-index

    61 publications

    5.5K citations

  2. Janssen (United States)

    Hopewell, United States

    5 h-index

    12 publications

    272 citations

  3. Springhouse

    Boston, United States

    3 h-index

    5 publications

    114 citations

  4. Vanderbilt University

    Nashville, United States

    2 h-index

    3 publications

    1.9K citations

  5. Leiden University

    Leiden, The Netherlands

    2 h-index

    4 publications

    119 citations

  6. University of Southern California

    Los Angeles, United States

    2 h-index

    3 publications

    1.7K citations

  7. University Hospital of Bern

    Bern, Switzerland

    2 h-index

    4 publications

    260 citations

  8. Lund University

    Lund, Sweden

    2 h-index

    8 publications

    96 citations

1–8 of 111

Venues

  1. Journal of Pharmacokinetics and Pharmacodynamics

    15 publications · 385 citations

    12

    h-index

  2. Journal of Pharmacokinetics and Biopharmaceutics

    9 publications · 1.2K citations

    9

    h-index

  3. Clinical Pharmacology & Therapeutics

    CPT · 5 publications · 472 citations

    5

    h-index

  4. Journal of Pharmaceutical Sciences

    3 publications · 197 citations

    3

    h-index

  5. British Journal of Clinical Pharmacology

    BJCP · 2 publications · 53 citations

    2

    h-index

1–5