Concepedia

Immune-mediated Synaptic Pruning

Immune-Mediated Synaptic Pruning is a neurodevelopmental process in which microglial cells selectively eliminate redundant or dysfunctional synapses during central nervous system maturation through immune signaling pathways, particularly involving complement cascade activation.

22

Publications

3K

Citations

203

Authors

75

Institutions

Publications per year

2017–2026

18

Parents

Publications

22

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Carl M. Sellgren, Jessica Gracias, Bradley Watmuff et al. · Nature Neuroscience · 2019 · 828 citations

, , +16

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

Ashley M. Laughney, Jing Hu, Nathaniel R. Campbell et al. · Nature Medicine · 2020 · 496 citations · Full text

, , +16

Prenatal infection leads to ASD-like behavior and altered synaptic pruning in the mouse offspring

Lourdes Fernández de Cossío, Andrea S. Guzmán, Suzanne van der Veldt et al. · Brain Behavior and Immunity · 2016 · 215 citations

, , +16

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

Balázs A. Györffy, Judit Kun, György Török et al. · Proceedings of the National Academy of Sciences · 2018 · 187 citations · Full text

, , +17

Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors

Carl M. Sellgren, Steven D. Sheridan, Jessica Gracias et al. · Molecular Psychiatry · 2016 · 173 citations · Full text

, , +17

1–5 of 22

Authors

203

  1. TF
    Ting Fu

    Massachusetts General Hospital, United States

    2 publications · 1K citations

    2

    h-index

  2. BA
    Balázs A. Györffy

    Eötvös Loránd University, Hungary

    2 publications · 230 citations

    2

    h-index

  3. RH
    Roy H. Perlis

    Massachusetts General Hospital, United States

    2 publications · 1K citations

    2

    h-index

  4. ÉB
    Éva Bulyáki

    Eötvös Loránd University, Hungary

    2 publications · 230 citations

    2

    h-index

  5. JG
    Jessica Gracias

    Karolinska Institutet, Sweden

    2 publications · 1K citations

    2

    h-index

1–5 of 203

Institutions

75

  1. Harvard University

    Cambridge, United States

    4 h-index

    19 publications

    9.5K citations

  2. Hungarian Academy of Sciences

    Budapest, Hungary

    2 h-index

    7 publications

    1K citations

  3. Massachusetts General Hospital

    Boston, United States

    2 h-index

    16 publications

    9.3K citations

  4. McGill University

    Montreal, Canada

    2 h-index

    6 publications

    1.1K citations

  5. Institute of Molecular Life Sciences

    Budapest, Hungary

    2 h-index

    3 publications

    273 citations

  6. Karolinska Institutet

    Stockholm, Sweden

    2 h-index

    3 publications

    1.8K citations

  7. Eötvös Loránd University

    Budapest, Hungary

    2 h-index

    23 publications

    2.4K citations

  8. Beth Israel Deaconess Medical Center

    Boston, United States

    1 h-index

    2 publications

    84 citations

1–8 of 75

Venues

  1. Brain Behavior and Immunity

    2 publications · 324 citations

    2

    h-index

  2. Journal of Neuroscience

    2 publications · 77 citations

    2

    h-index

  3. Science

    1 publications · 74 citations

    1

    h-index

  4. Frontiers in Immunology

    1 publications · 43 citations

    1

    h-index

  5. Journal of Neuroimmune Pharmacology

    JNIP · 1 publications · 132 citations

    1

    h-index

1–5