Concepedia

Hydrophobic Core Optimization

Hydrophobic Core Optimization is a protein engineering strategy that enhances thermostability by systematically refining the packing and composition of nonpolar residues within the protein's interior to maximize hydrophobic interactions and minimize structural flexibility.

61

Publications

3.4K

Citations

307

Authors

123

Institutions

Publications per year

2017–2026

10

Parents

Publications

61

De novo design of the hydrophobic cores of proteins

John R. Desjarlais, Tracy M. Handel · Protein Science · 1995 · 307 citations · Full text

, , +15

A test of lattice protein folding algorithms.

Kaizhi Yue, Klaus M. Fiebig, Paul D. Thomas et al. · Proceedings of the National Academy of Sciences · 1995 · 293 citations

, , +17

What makes a protein a protein? Hydrophobic core designs that specify stability and structural properties

Mary Munson, Suganthi Balasubramanian, Karen G. Fleming et al. · Protein Science · 1996 · 195 citations · Full text

, , +17

Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation

Shiroh Futaki, Mineo Niwa, Yoshinobu Baba et al. · Gene Therapy · 2004 · 166 citations

, , +7

Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme

James H. Hurley, Walter A. Baase, Brian W. Matthews · Journal of Molecular Biology · 1992 · 133 citations

, , +15

1–5 of 61

Authors

307

  1. MT
    Md Tamjidul Hoque

    University of New Orleans, United States

    3 publications · 79 citations

    3

    h-index

  2. HC
    Huiqing Cao

    Peking University, China

    3 publications · 183 citations

    3

    h-index

  3. FR
    Francesc Rabanal

    Universitat de Barcelona, Spain

    2 publications · 63 citations

    2

    h-index

  4. LS
    Laurence S. Dooley

    Monash University, Australia

    2 publications · 65 citations

    2

    h-index

  5. JR
    John R. Desjarlais

    Xencor (United States), United States

    2 publications · 394 citations

    2

    h-index

1–5 of 307

Institutions

123

  1. Collaborative Innovation Center of Chemical Science and Engineering Tianjin

    Tianjin, China

    3 h-index

    7 publications

    502 citations

  2. University of California, Berkeley

    Berkeley, United States

    3 h-index

    9 publications

    939 citations

  3. Monash University

    Melbourne, Australia

    3 h-index

    12 publications

    453 citations

  4. Peking University

    Beijing, China

    3 h-index

    16 publications

    1.1K citations

  5. The University of Tokyo

    Tokyo, Japan

    3 h-index

    9 publications

    245 citations

  6. Tianjin University

    Tianjin, China

    3 h-index

    15 publications

    882 citations

  7. Medical Research Council

    London, United Kingdom

    2 h-index

    7 publications

    510 citations

  8. Yale University

    New Haven, United States

    2 h-index

    9 publications

    1.5K citations

1–8 of 123

Venues

  1. Journal of Molecular Biology

    JMB · 7 publications · 464 citations

    7

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 4 publications · 156 citations

    4

    h-index

  3. Bioorganic & Medicinal Chemistry

    3 publications · 91 citations

    3

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 371 citations

    2

    h-index

  5. Protein Science

    PS · 2 publications · 502 citations

    2

    h-index

1–5