Concepedia

Hydration In Binding

Hydration in Binding is a biochemical phenomenon wherein water molecules mediate or stabilize the interaction between a ligand and its target macromolecule, thereby influencing binding affinity and specificity.

88

Publications

4.7K

Citations

288

Authors

134

Institutions

Publications per year

2017–2026

15

Variants

Binding Hydration

Parents

Publications

88

Chloride binding related to hydration products

M.V.A. Florea, H.J.H. Brouwers · Cement and Concrete Research · 2011 · 397 citations

, , +10

Studies of protein hydration in aqueous solution by direct NMR observation of individual protein-bound water molecules

Gottfried Otting, Kurt Wuethrich · Journal of the American Chemical Society · 1989 · 314 citations

, , +13

Counterion Specificity in the Formation of Ionic Micelles - Size, Hydration, and Hydrophobic Bonding Effects

Pasupati Mukerjee, Karol J. Mysels, Paz Kapauan · The Journal of Physical Chemistry · 1967 · 247 citations

, , +14

Estimating hydration changes upon biomolecular reactions from osmotic stress, high pressure, and preferential hydration experiments

Seishi Shimizu · Proceedings of the National Academy of Sciences · 2004 · 202 citations · Full text

, , +15

Hydration in drug design. 1. Multiple hydrogen-bonding features of water molecules in mediating protein-ligand interactions

C. S. Poornima, P. M. Dean · Journal of Computer-Aided Molecular Design · 1995 · 194 citations

, , +17

1–5 of 88

Authors

288

  1. WS
    Woody Sherman

    Schrodinger (United States), United States

    3 publications · 175 citations

    3

    h-index

  2. PM
    P. M. Dean

    University of Cambridge, United Kingdom

    3 publications · 382 citations

    3

    h-index

  3. TV
    Tigran V. Chalikian

    University of Toronto, Canada

    3 publications · 68 citations

    3

    h-index

  4. CS
    C. S. Poornima

    Bridge University, South Sudan

    3 publications · 382 citations

    3

    h-index

  5. DN
    David N. Dubins

    University of Toronto, Canada

    2 publications · 48 citations

    2

    h-index

1–5 of 288

Institutions

134

  1. University of Cambridge

    Cambridge, United Kingdom

    5 h-index

    10 publications

    884 citations

  2. Schrodinger (United States)

    New York, United States

    4 h-index

    8 publications

    474 citations

  3. Lund University

    Lund, Sweden

    3 h-index

    9 publications

    633 citations

  4. Bridge University

    Juba, South Sudan

    3 h-index

    3 publications

    382 citations

  5. University of Toronto

    Toronto, Canada

    3 h-index

    10 publications

    237 citations

  6. University at Buffalo, State University of New York

    Buffalo, United States

    2 h-index

    6 publications

    206 citations

  7. National University of Tucumán

    Tucumán, Argentina

    2 h-index

    8 publications

    168 citations

  8. Harvard University

    Cambridge, United States

    2 h-index

    14 publications

    504 citations

1–8 of 134

Venues

  1. The Journal of Physical Chemistry B

    6 publications · 270 citations

    6

    h-index

  2. Journal of the American Chemical Society

    JACS · 5 publications · 521 citations

    5

    h-index

  3. Journal of Chemical Theory and Computation

    JCTC · 5 publications · 313 citations

    5

    h-index

  4. Journal of Medicinal Chemistry

    4 publications · 129 citations

    4

    h-index

  5. Journal of Computer-Aided Molecular Design

    3 publications · 382 citations

    3

    h-index

1–5