Humanization of Antibody Libraries is a methodological framework within recombinant antibody engineering that involves the structural refinement of non-human antibody repertoires through the systematic replacement of framework and complementarity-determining regions with human germline sequences to minimize immunogenicity while preserving antigen-binding specificity.
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Antibody Humanization Using Monovalent Phage Display
Manuel Baca, Leonard G. Presta, Shane J. O'Connor et al. · Journal of Biological Chemistry · 1997 · 148 citations · Full text
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Authors
291
- MLMarie‐Paule Lefranc
Centre National de la Recherche Scientifique, France
3 publications · 156 citations
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98
Centre National de la Recherche Scientifique
Paris, France
4 h-index
15 publications
576 citations
Scripps Research Institute
San Diego, United States
3 h-index
11 publications
1K citations
Service de Santé des Armées
Metz, France
3 h-index
5 publications
262 citations
Laboratoire d'Informatique Gaspard-Monge
Champs-sur-Marne, France
3 h-index
7 publications
232 citations
Institut de Génétique Humaine
Montpellier, France
3 h-index
7 publications
232 citations
University of Bath
Bath, United Kingdom
2 h-index
4 publications
208 citations
Merck & Co., Inc., Rahway, NJ, USA (United States)
Rahway, United States
2 h-index
2 publications
227 citations
University of Chemistry and Technology, Prague
Prague, Czechia
1 h-index
2 publications
380 citations
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Venues
- Journal of Biological Chemistry
JBC · 4 publications · 363 citations
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- mAbs
4 publications · 276 citations
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- Protein Engineering Design and Selection
PEDS · 3 publications · 112 citations
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- Biotechnology Journal
2 publications · 43 citations
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- Methods in molecular biology
Book series · 2 publications · 64 citations
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