Concepedia

Host-directed Therapy

Host-Directed Therapy is a therapeutic strategy that modulates host immune responses and cellular functions to enhance pathogen clearance, limit tissue damage, and promote disease resolution, distinguishing it from pathogen-targeted approaches by focusing on the host’s biological mechanisms rather than direct antimicrobial activity.

221

Publications

11.5K

Citations

1.9K

Authors

632

Institutions

Publications per year

2017–2026

178

Variants

Hdt

Parents

Publications

221

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

Katrin D. Mayer-Barber, Bruno B. Andrade, Sandra D. Oland et al. · Nature · 2014 · 780 citations · Full text

, , +12

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

David M. Tobin, Francisco J. Roca, Sungwhan F. Oh et al. · Cell · 2012 · 572 citations · Full text

, , +16

A major role for ferroptosis in <i>Mycobacterium tuberculosis</i>–induced cell death and tissue necrosis

Eduardo P. Amaral, Diego L. Costa, Sivaranjani Namasivayam et al. · The Journal of Experimental Medicine · 2019 · 448 citations · Full text

, , +16

Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial

Fanping Meng, Ruonan Xu, Siyu Wang et al. · Signal Transduction and Targeted Therapy · 2020 · 349 citations · Full text

, , +15

Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis

Pan Luo, Lin Qiu, Yi Liu et al. · American Journal of Tropical Medicine and Hygiene · 2020 · 267 citations · Full text

, , +16

1–5 of 221

Authors

1.9K

  1. BB
    Bruno B. Andrade

    Fundação Oswaldo Cruz, Brazil

    7 publications · 1.5K citations

    7

    h-index

  2. SH
    Stefan H. E. Kaufmann

    Max Planck Institute for Infection Biology, Germany

    6 publications · 437 citations

    6

    h-index

  3. TH
    Tom H. M. Ottenhoff

    Leiden University Medical Center, Netherlands

    6 publications · 296 citations

    6

    h-index

  4. WR
    William R. Bishai

    Johns Hopkins University, United States

    6 publications · 183 citations

    6

    h-index

  5. AZ
    Alimuddin Zumla

    University College London, United Kingdom

    6 publications · 548 citations

    6

    h-index

1–5 of 1.9K

Institutions

632

  1. Johns Hopkins University

    Baltimore, United States

    12 h-index

    70 publications

    3K citations

  2. University College London

    London, United Kingdom

    12 h-index

    19 publications

    940 citations

  3. University of Cape Town

    Rondebosch, South Africa

    12 h-index

    63 publications

    2.1K citations

  4. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    11 h-index

    55 publications

    13.6K citations

  5. Johns Hopkins Medicine

    Baltimore, United States

    9 h-index

    57 publications

    2.4K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    9 h-index

    24 publications

    959 citations

  7. National Institutes of Health

    Bethesda, United States

    8 h-index

    45 publications

    12.9K citations

  8. Max Planck Institute for Infection Biology

    Berlin, Germany

    8 h-index

    24 publications

    1.9K citations

1–8 of 632

Venues

  1. Frontiers in Immunology

    17 publications · 628 citations

    15

    h-index

  2. Scientific Reports

    14 publications · 539 citations

    14

    h-index

  3. The Journal of Infectious Diseases

    JID · 13 publications · 655 citations

    12

    h-index

  4. Nature Communications

    7 publications · 583 citations

    7

    h-index

  5. Antimicrobial Agents and Chemotherapy

    AAC · 7 publications · 151 citations

    7

    h-index

1–5