Concepedia

Homology Model Optimization

Homology Model Optimization is a computational methodology that refines the structural accuracy of a predicted protein model derived from evolutionary-related templates by systematically adjusting its geometric and energetic properties to better conform to physicochemical principles and experimental constraints.

90

Publications

5.5K

Citations

625

Authors

189

Institutions

Publications per year

2017–2026

16

Variants

Homology Model Refinement

Parents

Publications

90

Increasing the precision of comparative models with YASARA NOVA—a self‐parameterizing force field

Elmar Krieger, Günther Koraimann, Gert Vriend · Proteins Structure Function and Bioinformatics · 2002 · 1.5K citations · Full text

, , +17

EasyModeller: A graphical interface to MODELLER

Bhusan K. Kuntal, Polamarasetty Aparoy, Pallu Reddanna · BMC Research Notes · 2010 · 229 citations · Full text

, , +13

Toward high‐resolution homology modeling of antibody F<sub>v</sub> regions and application to antibody–antigen docking

Arvind Sivasubramanian, Aroop Sircar, Sidhartha Chaudhury et al. · Proteins Structure Function and Bioinformatics · 2008 · 188 citations · Full text

, , +17

Classifier ensembles for protein structural class prediction with varying homology

Kanaka Durga Kedarisetti, Lukasz Kurgan, Scott Dick · Biochemical and Biophysical Research Communications · 2006 · 164 citations

, , +14

Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme:  Design, Synthesis, and Structure−Activity Relationships

James J.‐W. Duan, Lihua Chen, Zelda R. Wasserman et al. · Journal of Medicinal Chemistry · 2002 · 119 citations · Full text

, , +17

1–5 of 90

Authors

625

  1. RA
    Ruben Abagyan

    University of California San Diego, United States

    4 publications · 290 citations

    4

    h-index

  2. PR
    Pallu Reddanna

    University of Hyderabad, India

    2 publications · 251 citations

    2

    h-index

  3. PA
    Polamarasetty Aparoy

    University of Hyderabad, India

    2 publications · 251 citations

    2

    h-index

  4. DB
    David Baker

    University of Washington, United States

    2 publications · 177 citations

    2

    h-index

  5. MT
    Maxim Totrov

    Molsoft (United States), United States

    2 publications · 126 citations

    2

    h-index

1–5 of 625

Institutions

189

  1. New York University

    New York, United States

    3 h-index

    3 publications

    194 citations

  2. National Institutes of Health

    Bethesda, United States

    3 h-index

    3 publications

    134 citations

  3. Scripps Research Institute

    San Diego, United States

    3 h-index

    3 publications

    125 citations

  4. Seoul National University

    Seoul, South Korea

    3 h-index

    3 publications

    110 citations

  5. Johns Hopkins University

    Baltimore, United States

    2 h-index

    2 publications

    256 citations

  6. University of Hyderabad

    Hyderabad, India

    2 h-index

    2 publications

    251 citations

  7. University of Washington

    Seattle, United States

    2 h-index

    2 publications

    177 citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    2 publications

    177 citations

1–8 of 189

Venues

  1. Journal of Medicinal Chemistry

    13 publications · 718 citations

    13

    h-index

  2. Journal of Molecular Graphics and Modelling

    5 publications · 215 citations

    5

    h-index

  3. Proteins Structure Function and Bioinformatics

    4 publications · 1.8K citations

    4

    h-index

  4. Journal of Molecular Modeling

    4 publications · 51 citations

    4

    h-index

  5. Journal of Molecular Biology

    JMB · 3 publications · 201 citations

    3

    h-index

1–5