Concepedia

Histone Serotonylation

Histone Serotonylation is a histone post-translational modification in which serotonin is covalently attached to a glutamine residue on a histone protein, specifically catalyzed by transglutaminases, thereby altering chromatin structure and regulating gene expression.

9

Publications

815

Citations

88

Authors

34

Institutions

Publications per year

2017–2026

9

Parents

Publications

9

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3

Lorna A. Farrelly, Robert E. Thompson, Shuai Zhao et al. · Nature · 2019 · 475 citations

, , +8

Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout

Shuai Zhao, Kelly N. Chuh, Baichao Zhang et al. · Proceedings of the National Academy of Sciences · 2021 · 82 citations · Full text

, , +16

Histone serotonylation regulates ependymoma tumorigenesis

Hsiao‐Chi Chen, Peihao He, Malcolm F. McDonald et al. · Nature · 2024 · 49 citations · Full text

, , +12

Structural insights into the recognition of histone H3Q5 serotonylation by WDR5

Jie Zhao, Wanbiao Chen, Yi Pan et al. · Science Advances · 2021 · 48 citations · Full text

, , +8

Bidirectional histone monoaminylation dynamics regulate neural rhythmicity

Qingfei Zheng, Benjamin H. Weekley, David A. Vinson et al. · Nature · 2025 · 47 citations · Full text

, , +16

1–5 of 9

Authors

88

  1. IM
    Ian Maze

    Icahn School of Medicine at Mount Sinai, United States

    6 publications · 689 citations

    6

    h-index

  2. LS
    Li Shen

    Icahn School of Medicine at Mount Sinai, United States

    5 publications · 607 citations

    5

    h-index

  3. TW
    Tom W. Muir

    Rockefeller University, United States

    5 publications · 660 citations

    5

    h-index

  4. AR
    Aarthi Ramakrishnan

    Icahn School of Medicine at Mount Sinai, United States

    5 publications · 607 citations

    5

    h-index

  5. RE
    Robert E. Thompson

    G & A Technical Software (United States), United States

    4 publications · 622 citations

    4

    h-index

1–5 of 88

Institutions

34

  1. Icahn School of Medicine at Mount Sinai

    New York, United States

    6 h-index

    40 publications

    5.5K citations

  2. Allen Institute for Brain Science

    Seattle, United States

    6 h-index

    39 publications

    5K citations

  3. Princeton University

    Princeton, United States

    5 h-index

    17 publications

    2.1K citations

  4. Tsinghua University

    Beijing, China

    4 h-index

    17 publications

    2.2K citations

  5. Rockefeller University

    New York, United States

    4 h-index

    7 publications

    2K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    3 publications

    94 citations

  7. Center for Life Sciences

    Beijing, China

    3 h-index

    5 publications

    1.6K citations

  8. Tri-Institutional PhD Program in Chemical Biology

    New York, United States

    2 h-index

    6 publications

    195 citations

1–8 of 34

Venues

  1. Nature

    3 publications · 571 citations

    3

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 120 citations

    2

    h-index

  3. Signal Transduction and Targeted Therapy

    1 publications · 29 citations

    1

    h-index

  4. Science Advances

    1 publications · 48 citations

    1

    h-index

  5. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 1 publications · 18 citations

    1

    h-index

1–5