Concepedia

Heterogeneity-driven Resistance

Heterogeneity-Driven Resistance is a resistance mechanism in which variability across biological, genetic, or environmental dimensions within a population or microenvironment differentially modulates drug response, thereby enabling subpopulations with intrinsic or acquired tolerance to survive therapeutic intervention.

7

Publications

502

Citations

37

Authors

20

Institutions

Publications per year

2017–2026

2

Parents

Publications

7

Drug concentration heterogeneity facilitates the evolution of drug resistance

Thomas B. Kepler, Alan S. Perelson · Proceedings of the National Academy of Sciences · 1998 · 280 citations · Full text

, , +13

Resistance heterogeneity in methicillin-resistant<i>Staphylococcus aureus</i>

Peter Matthews, P. R. Stewart · FEMS Microbiology Letters · 1984 · 63 citations

, , +16

Tuning Spatial Profiles of Selection Pressure to Modulate the Evolution of Drug Resistance

Maxwell G. De Jong, Kevin B. Wood · Physical Review Letters · 2018 · 46 citations

, , +17

Broad RTK-targeted therapy overcomes molecular heterogeneity-driven resistance to cetuximab via vectored immunoprophylaxis in colorectal cancer

Shi Hu, Haibin Dai, Tian Li et al. · Cancer Letters · 2016 · 35 citations

, , +17

NIR Photodynamic Destruction of PDAC and HNSCC Nodules Using Triple-Receptor-Targeted Photoimmuno-Nanoconjugates: Targeting Heterogeneity in Cancer

Shazia Bano, Girgis Obaid, Joseph W. R. Swain et al. · Journal of Clinical Medicine · 2020 · 28 citations · Full text

, , +17

1–5 of 7

Authors

37

  1. MY
    Marina Yamada

    Keio University, Japan

    1 publications · 28 citations

    1

    h-index

  2. RN
    Randal N. Johnston

    University of Calgary, Canada

    1 publications · 27 citations

    1

    h-index

  3. RJ
    Ruobing Jin

    Second Military Medical University, China

    1 publications · 35 citations

    1

    h-index

  4. YY
    Yongji Yang

    Second Military Medical University, China

    1 publications · 35 citations

    1

    h-index

  5. MM
    Michael M. Gottesman

    National Cancer Institute, United States

    1 publications · 23 citations

    1

    h-index

1–5 of 37

Institutions

20

  1. Nanjing General Hospital of Nanjing Military Command

    Nanjing, China

    1 h-index

    1 publications

    35 citations

  2. Mayo Clinic in Arizona

    Scottsdale, United States

    1 h-index

    1 publications

    28 citations

  3. North Carolina State University

    Raleigh, United States

    1 h-index

    2 publications

    560 citations

  4. University of Michigan

    Ann Arbor, United States

    1 h-index

    2 publications

    92 citations

  5. National Institutes of Health

    Bethesda, United States

    1 h-index

    1 publications

    23 citations

  6. Dartmouth College

    Hanover, United States

    1 h-index

    1 publications

    28 citations

  7. Second Military Medical University

    Shanghai, China

    1 h-index

    15 publications

    525 citations

  8. Center for Cancer Research

    Bethesda, United States

    1 h-index

    1 publications

    23 citations

1–8 of 20

Venues

  1. British Journal of Cancer

    BJC · 1 publications · 27 citations

    1

    h-index

  2. Physical Review Letters

    PRL · 1 publications · 46 citations

    1

    h-index

  3. FEMS Microbiology Letters

    1 publications · 63 citations

    1

    h-index

  4. Trends in Molecular Medicine

    1 publications · 23 citations

    1

    h-index

  5. Cancer Letters

    1 publications · 35 citations

    1

    h-index

1–5