Concepedia

Helicase Coupling

Helicase Coupling is a molecular mechanism in DNA replication that integrates the helicase enzyme with the replisome machinery by coordinating its unwinding activity with the progression of DNA polymerases, thereby ensuring efficient and synchronized fork progression during genome duplication.

54

Publications

5K

Citations

223

Authors

101

Institutions

Publications per year

2017–2026

7

Parents

Publications

54

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

James Chen, Brandon Malone, Eliza Llewellyn et al. · Cell · 2020 · 500 citations · Full text

, , +16

Coupling of a Replicative Polymerase and Helicase: A τ–DnaB Interaction Mediates Rapid Replication Fork Movement

Sungsub Kim, H. Garry Dallmann, Charles S. McHenry et al. · Cell · 1996 · 362 citations · Full text

, , +17

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

Marenda A. Wilson, Youngho Kwon, Yuanyuan Xu et al. · Nature · 2013 · 314 citations

, , +16

Human Transcription-Repair Coupling Factor CSB/ERCC6 Is a DNA-stimulated ATPase but Is Not a Helicase and Does Not Disrupt the Ternary Transcription Complex of Stalled RNA Polymerase II

Christopher P. Selby, Aziz Sancar · Journal of Biological Chemistry · 1997 · 265 citations · Full text

, , +17

A key role for Ctf4 in coupling the MCM2‐7 helicase to DNA polymerase α within the eukaryotic replisome

Agnieszka Gambus, Frederick van Deursen, Dimitris Polychronopoulos et al. · The EMBO Journal · 2009 · 258 citations · Full text

, , +17

1–5 of 54

Authors

223

  1. MS
    Mark S. Dillingham

    University of Bristol, United Kingdom

    4 publications · 407 citations

    4

    h-index

  2. AS
    Aziz Sancar

    University of North Carolina at Chapel Hill, United States

    3 publications · 537 citations

    3

    h-index

  3. DB
    Dale B. Wigley

    University of Oxford, United Kingdom

    3 publications · 343 citations

    3

    h-index

  4. PS
    Panos Soultanas

    University of Nottingham, United Kingdom

    3 publications · 343 citations

    3

    h-index

  5. MR
    Martin R. Webb

    The Francis Crick Institute, United Kingdom

    3 publications · 288 citations

    3

    h-index

1–5 of 223

Institutions

101

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    4 publications

    286 citations

  2. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    4 h-index

    9 publications

    1.2K citations

  3. University of Oxford

    Oxford, United Kingdom

    4 h-index

    15 publications

    1.5K citations

  4. Rockefeller University

    New York, United States

    4 h-index

    26 publications

    6.2K citations

  5. Washington University in St. Louis

    St Louis, United States

    3 h-index

    8 publications

    720 citations

  6. Memorial Sloan Kettering Cancer Center

    New York, United States

    3 h-index

    4 publications

    483 citations

  7. Université Paris Cité

    Paris, France

    2 h-index

    10 publications

    455 citations

  8. University of Manchester

    Manchester, United Kingdom

    2 h-index

    5 publications

    1.2K citations

1–8 of 101

Venues

  1. Journal of Biological Chemistry

    JBC · 11 publications · 1.1K citations

    11

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 332 citations

    6

    h-index

  3. Journal of Molecular Biology

    JMB · 6 publications · 346 citations

    6

    h-index

  4. Nucleic Acids Research

    5 publications · 271 citations

    5

    h-index

  5. Cell

    3 publications · 1K citations

    3

    h-index

1–5