Concepedia

Grapefruit Interactions

Grapefruit Interactions is a drug-nutrient interaction characterized by the inhibition of cytochrome P450 3A4 (CYP3A4) enzyme activity and modulation of drug transporters, primarily mediated by furanocoumarins in grapefruit, which leads to altered pharmacokinetics and increased systemic exposure of certain orally administered medications.

23

Publications

1.5K

Citations

64

Authors

32

Institutions

Publications per year

2017–2026

4

Variants

Grapefruit-drug Interactions

Parents

Publications

23

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice*

Murray P. Ducharme, L H Warbasse, David J. Edwards · Clinical Pharmacology & Therapeutics · 1995 · 351 citations

, , +15

Drug Interactions with Grapefruit Juice

Barbara Ameer, Randy A. Weintraub · Clinical Pharmacokinetics · 1997 · 349 citations

, , +6

Grapefruit-felodipine interaction: Effect of unprocessed fruit and probable active ingredients

Damian M. Bailey · Clinical Pharmacology & Therapeutics · 2000 · 162 citations

, , +13

Variation of Flavonoids and Furanocoumarins in Grapefruit Juices:  A Potential Source of Variability in Grapefruit Juice−Drug Interaction Studies

Whocely Victor de Castro, Susanne U. Mertens‐Talcott, Anke Rubner et al. · Journal of Agricultural and Food Chemistry · 2005 · 116 citations

, , +10

A Refuge for Red Scale Under Control by Aphytis: Structural Aspects

William W. Murdoch, Robert F. Luck, Sandra J. Walde et al. · Ecology · 1989 · 59 citations

, , +13

1–5 of 23

Authors

64

  1. DG
    David G. Bailey

    Western University, Canada

    2 publications · 27 citations

    2

    h-index

  2. SU
    Susanne U. Mertens‐Talcott

    Texas A&M University, United States

    1 publications · 116 citations

    1

    h-index

  3. DJ
    David J. Greenblatt

    Tufts University, United States

    1 publications · 22 citations

    1

    h-index

  4. PC
    Paul Cancalon

    Florida State University, United States

    1 publications · 22 citations

    1

    h-index

  5. GM
    G Massé

    Tufts University, United States

    1 publications · 22 citations

    1

    h-index

1–5 of 64

Institutions

32

  1. Western University

    London, Canada

    3 h-index

    9 publications

    267 citations

  2. London Health Sciences Centre

    London, Canada

    2 h-index

    3 publications

    188 citations

  3. Lawson Health Research Institute

    London, Canada

    2 h-index

    3 publications

    40 citations

  4. University of California, Santa Barbara

    Santa Barbara, United States

    1 h-index

    1 publications

    59 citations

  5. Hebrew University of Jerusalem

    Jerusalem, Israel

    1 h-index

    4 publications

    148 citations

  6. Jean Mayer Human Nutrition Research Center on Aging

    Boston, United States

    1 h-index

    1 publications

    22 citations

  7. Universidade de São Paulo

    São Paulo, Brazil

    1 h-index

    3 publications

    51 citations

  8. University of Karachi

    Karachi, Pakistan

    1 h-index

    1 publications

    45 citations

1–8 of 32

Venues

  1. PubMed

    Repository · 6 publications · 136 citations

    6

    h-index

  2. Clinical Pharmacology & Therapeutics

    CPT · 4 publications · 591 citations

    4

    h-index

  3. Journal of Natural Products

    1 publications · 17 citations

    1

    h-index

  4. Entomologia Experimentalis et Applicata

    1 publications · 11 citations

    1

    h-index

  5. Florida Entomologist

    1 publications · 30 citations

    1

    h-index

1–5