Concepedia

Genotype-based Dose Optimization

Genotype-Based Dose Optimization is a pharmacogenetic strategy that systematically tailors drug dosage regimens to an individual's genetic profile to enhance therapeutic efficacy and minimize adverse drug reactions.

57

Publications

5K

Citations

536

Authors

217

Institutions

Publications per year

2017–2026

12

Variants

Pharmacogenetic Dose Optimization

Parents

Publications

57

A Randomized Trial of Genotype-Guided Dosing of Warfarin

Munir Pirmohamed, Girvan Burnside, Niclas Eriksson et al. · New England Journal of Medicine · 2013 · 808 citations · Full text

, , +14

A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing

Stephen E. Kimmel, Benjamin French, Scott E. Kasner et al. · New England Journal of Medicine · 2013 · 749 citations · Full text

, , +17

Upfront Genotyping of <i>DPYD</i>*<i>2A</i> to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis

Maarten J. Deenen, Didier Meulendijks, Annemieke Cats et al. · Journal of Clinical Oncology · 2015 · 345 citations · Full text

, , +17

Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing

Kelly E. Caudle, Caroline F. Thorn, Teri E. Klein et al. · Clinical Pharmacology & Therapeutics · 2013 · 322 citations · Full text

, , +17

Preemptive Genotyping for Personalized Medicine: Design of the Right Drug, Right Dose, Right Time—Using Genomic Data to Individualize Treatment Protocol

Suzette J. Bielinski, Janet E. Olson, Jyotishman Pathak et al. · Mayo Clinic Proceedings · 2014 · 304 citations · Full text

, , +17

1–5 of 57

Authors

536

  1. JH
    Jan H.M. Schellens

    The Netherlands Cancer Institute, Netherlands

    4 publications · 588 citations

    4

    h-index

  2. AC
    Annemieke Cats

    The Netherlands Cancer Institute, Netherlands

    4 publications · 588 citations

    4

    h-index

  3. MW
    Mia Wadelius

    Uppsala University, Sweden

    4 publications · 1.1K citations

    4

    h-index

  4. BF
    Brian F. Gage

    Washington University in St. Louis, United States

    4 publications · 1.2K citations

    4

    h-index

  5. MP
    Munir Pirmohamed

    University of Liverpool, United Kingdom

    3 publications · 1.1K citations

    3

    h-index

1–5 of 536

Institutions

217

  1. Radboud University Nijmegen

    Nijmegen, The Netherlands

    6 h-index

    28 publications

    4.9K citations

  2. Utrecht University

    Utrecht, The Netherlands

    6 h-index

    22 publications

    5.6K citations

  3. Leiden University Medical Center

    Leiden, The Netherlands

    5 h-index

    11 publications

    1K citations

  4. University of Liverpool

    Liverpool, United Kingdom

    5 h-index

    13 publications

    5.5K citations

  5. University of Pennsylvania

    Philadelphia, United States

    4 h-index

    16 publications

    4.8K citations

  6. Washington University in St. Louis

    St Louis, United States

    4 h-index

    20 publications

    4.8K citations

  7. Mayo Clinic

    Rochester, United States

    4 h-index

    26 publications

    4.8K citations

  8. The Netherlands Cancer Institute

    Amsterdam, The Netherlands

    4 h-index

    27 publications

    5.3K citations

1–8 of 217

Venues

  1. Clinical Pharmacology & Therapeutics

    CPT · 5 publications · 717 citations

    5

    h-index

  2. European Journal of Clinical Pharmacology

    4 publications · 174 citations

    4

    h-index

  3. Pharmacogenomics

    3 publications · 122 citations

    3

    h-index

  4. European Journal of Cancer

    2 publications · 144 citations

    2

    h-index

  5. Thrombosis and Haemostasis

    2 publications · 28 citations

    2

    h-index

1–5