Concepedia

Gene Disruption

Gene Disruption is a molecular genetic technique that belongs to the class of genome editing methods, distinguished by its targeted introduction of double-strand breaks in DNA to inactivate or alter the function of a specific gene.

1.5K

Publications

162.8K

Citations

7.5K

Authors

1.6K

Institutions

Publications per year

2017–2026

226

Parents

Publications

1.5K

The mutational constraint spectrum quantified from variation in 141,456 humans

Konrad J. Karczewski, Laurent C. Francioli, Grace Tiao et al. · Nature · 2020 · 10.1K citations · Full text

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Designer deletion strains derived fromSaccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications

Carrie Baker Brachmann, Adrian Davies, Gregory J. Cost et al. · Yeast · 1998 · 3.6K citations

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New heterologous modules for classical or PCR‐based gene disruptions in <i>Saccharomyces cerevisiae</i>

Achim Wach, Arndt Brachat, Rainer Pöhlmann et al. · Yeast · 1994 · 2.6K citations

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Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant

Peter Cherepanov, Wilfried Wackernagel · Gene · 1995 · 2K citations

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Three new dominant drug resistance cassettes for gene disruption inSaccharomyces cerevisiae

Alan L. Goldstein, John H. McCusker · Yeast · 1999 · 1.9K citations

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1–5 of 1.5K

Authors

7.5K

  1. TY
    Takashi Yamamoto

    Hiroshima University, Japan

    12 publications · 651 citations

    12

    h-index

  2. YS
    Yasuyoshi Sakai

    Kyoto University, Japan

    8 publications · 379 citations

    8

    h-index

  3. YO
    Yasuo Ohnishi

    The University of Tokyo, Japan

    8 publications · 327 citations

    8

    h-index

  4. TS
    Tetsushi Sakuma

    Hiroshima University, Japan

    8 publications · 456 citations

    8

    h-index

  5. HT
    Hiroshi Takagi

    Nara Institute of Science and Technology, Japan

    8 publications · 465 citations

    8

    h-index

1–5 of 7.5K

Institutions

1.6K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    34 h-index

    147 publications

    58.9K citations

  2. Harvard University

    Cambridge, United States

    33 h-index

    152 publications

    173.8K citations

  3. Kyoto University

    Kyoto, Japan

    32 h-index

    171 publications

    14.9K citations

  4. The University of Tokyo

    Tokyo, Japan

    32 h-index

    203 publications

    15.4K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    27 h-index

    170 publications

    21.6K citations

  6. Massachusetts Institute of Technology

    Cambridge, United States

    25 h-index

    70 publications

    6K citations

  7. National Institutes of Health

    Bethesda, United States

    24 h-index

    121 publications

    37.2K citations

  8. Chinese Academy of Sciences

    Beijing, China

    24 h-index

    135 publications

    9.4K citations

1–8 of 1.6K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 75 publications · 15.6K citations

    60

    h-index

  2. Journal of Bacteriology

    JB · 83 publications · 8.4K citations

    53

    h-index

  3. Molecular and Cellular Biology

    MCB · 83 publications · 6.4K citations

    48

    h-index

  4. Journal of Biological Chemistry

    JBC · 48 publications · 5.9K citations

    39

    h-index

  5. Applied and Environmental Microbiology

    AEM · 54 publications · 3.9K citations

    37

    h-index

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