Concepedia

Gene Cluster Engineering

Gene Cluster Engineering is a synthetic biology methodology that involves the design, assembly, and optimization of co-regulated sets of genes responsible for specific metabolic pathways, distinguished by its focus on the coordinated manipulation of genetically linked enzymes to achieve desired biosynthetic functions.

80

Publications

4.6K

Citations

378

Authors

117

Institutions

Publications per year

2017–2026

32

Parents

Publications

80

Functional optimization of gene clusters by combinatorial design and assembly

Michael J. Smanski, Swapnil Bhatia, Dehua Zhao et al. · Nature Biotechnology · 2014 · 353 citations

, , +12

A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis

Marnix H. Medema, Peter Cimermančič, Andrej Săli et al. · PLoS Computational Biology · 2014 · 228 citations · Full text

, , +17

Engineered<i>Streptomyces avermitilis</i>Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites

Mamoru Komatsu, Kyoko Komatsu, Hanae Koiwai et al. · ACS Synthetic Biology · 2013 · 224 citations

, , +17

Production of Plant-Specific Flavanones by <i>Escherichia coli</i> Containing an Artificial Gene Cluster

Eui Il Hwang, Masafumi Kaneko, Yasuo Ohnishi et al. · Applied and Environmental Microbiology · 2003 · 221 citations · Full text

, , +16

Interrogating the Function of Metazoan Histones using Engineered Gene Clusters

Daniel J. McKay, Stephen Klusza, Taylor J.R. Penke et al. · Developmental Cell · 2015 · 191 citations · Full text

, , +14

1–5 of 80

Authors

378

  1. YZ
    Youming Zhang

    Shandong University, China

    7 publications · 422 citations

    7

    h-index

  2. HT
    Huarong Tan

    Institute of Microbiology, China

    4 publications · 126 citations

    4

    h-index

  3. KS
    Kazuo Shin‐ya

    National Institute of Advanced Industrial Science and Technology, Japan

    3 publications · 277 citations

    4

    h-index

  4. RM
    Rolf Müller

    Saarland University, Germany

    4 publications · 379 citations

    4

    h-index

  5. JH
    Junko Hashimoto

    Japan Biological Informatics Consortium, Japan

    3 publications · 277 citations

    4

    h-index

1–5 of 378

Institutions

117

  1. Chinese Academy of Sciences

    Beijing, China

    9 h-index

    38 publications

    1.1K citations

  2. Shandong University

    Jinan, China

    7 h-index

    37 publications

    3K citations

  3. Microbiology Institute of Shaanxi

    Xi'an, China

    6 h-index

    26 publications

    790 citations

  4. Saarland University

    Saarbrücken, Germany

    6 h-index

    21 publications

    1.5K citations

  5. State Key Laboratory of Microbial Technology

    Jinan, China

    6 h-index

    26 publications

    2.7K citations

  6. Institute of Microbiology

    Beijing, China

    6 h-index

    26 publications

    790 citations

  7. Helmholtz Institute for Pharmaceutical Research Saarland

    Saarbrücken, Germany

    5 h-index

    13 publications

    877 citations

  8. Kitasato University

    Tokyo, Japan

    5 h-index

    21 publications

    1.7K citations

1–8 of 117

Venues

  1. Microbial Cell Factories

    7 publications · 246 citations

    7

    h-index

  2. Applied Microbiology and Biotechnology

    5 publications · 335 citations

    6

    h-index

  3. The Journal of Antibiotics

    4 publications · 82 citations

    5

    h-index

  4. Metabolic Engineering

    4 publications · 232 citations

    4

    h-index

  5. ACS Synthetic Biology

    4 publications · 408 citations

    4

    h-index

1–5