Concepedia

Geminin-mediated Replication Control

Geminin-Mediated Replication Control is a regulatory mechanism in eukaryotic DNA replication that prevents relicensing of origins during S and G2 phases by inhibiting the assembly of the pre-replicative complex through the targeted degradation of Cdt1, thereby ensuring precise duplication of the genome within a single cell cycle.

47

Publications

4.9K

Citations

190

Authors

80

Institutions

Publications per year

2017–2026

4

Parents

Publications

47

Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis

Thomas J. McGarry, Marc W. Kirschner · Cell · 1998 · 896 citations · Full text

, , +14

Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1

James A. Wohlschlegel, Brian T. Dwyer, Suman Kumar Dhar et al. · Science · 2000 · 691 citations

, , +17

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

Shusuke Tada, Anatoliy Li, Domenico Maiorano et al. · Nature Cell Biology · 2001 · 449 citations

, , +6

Replication from oriP of Epstein-Barr Virus Requires Human ORC and Is Inhibited by Geminin

Suman Kumar Dhar, Kenichi Yoshida, Yuichi Machida et al. · Cell · 2001 · 293 citations · Full text

, , +10

HBO1 Histone Acetylase Activity Is Essential for DNA Replication Licensing and Inhibited by Geminin

Benoît Miotto, Kevin Struhl · Molecular Cell · 2010 · 245 citations · Full text

, , +14

1–5 of 47

Authors

190

  1. AD
    Anindya Dutta

    University of Virginia, United States

    7 publications · 1.4K citations

    7

    h-index

  2. MD
    Melvin Depamphilis

    Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States

    4 publications · 195 citations

    4

    h-index

  3. TJ
    Thomas J. McGarry

    Northwestern University, United States

    4 publications · 1K citations

    4

    h-index

  4. JJ
    J. Julian Blow

    University of Dundee, United Kingdom

    3 publications · 602 citations

    3

    h-index

  5. ST
    Stavros Taraviras

    University of Patras, Greece

    3 publications · 59 citations

    3

    h-index

1–5 of 190

Institutions

80

  1. Harvard University

    Cambridge, United States

    7 h-index

    21 publications

    8.1K citations

  2. Brigham and Women's Hospital

    Boston, United States

    4 h-index

    11 publications

    4.3K citations

  3. University of Virginia

    Charlottesville, United States

    3 h-index

    9 publications

    1.1K citations

  4. University of Patras

    Pátrai, Greece

    3 h-index

    21 publications

    536 citations

  5. Institut de Génétique Humaine

    Montpellier, France

    3 h-index

    7 publications

    1.2K citations

  6. University of Dundee

    Dundee, United Kingdom

    3 h-index

    6 publications

    1.6K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    12 publications

    1.4K citations

  8. Eunice Kennedy Shriver National Institute of Child Health and Human Development

    Bethesda, United States

    3 h-index

    9 publications

    403 citations

1–8 of 80

Venues

  1. Journal of Biological Chemistry

    JBC · 7 publications · 220 citations

    7

    h-index

  2. Cell Cycle

    4 publications · 65 citations

    4

    h-index

  3. The EMBO Journal

    3 publications · 365 citations

    3

    h-index

  4. Oncogene

    2 publications · 99 citations

    2

    h-index

  5. Cancer Research

    2 publications · 151 citations

    2

    h-index

1–5