Concepedia

Gc Box

GC Box is a cis-regulatory DNA sequence element, specifically a promoter motif enriched in guanine and cytosine nucleotides, that serves as a binding site for transcription factors such as SP1 and thereby facilitates the recruitment of RNA polymerase II to initiate gene transcription.

585

Publications

37.5K

Citations

2.3K

Authors

566

Institutions

Publications per year

2017–2026

7

Variants

Gc-rich Box

Parents

Publications

585

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

Michael R. Briggs, James T. Kadonaga, Stephen P. Bell et al. · Science · 1986 · 1.5K citations

, , +17

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase <sub>1</sub>  gene

Venugopal Radjendirane, Anil K. Jaiswal · Proceedings of the National Academy of Sciences · 1996 · 1K citations · Full text

, , +16

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

Stephen P. Jackson, Judy J. MacDonald, Susan P. Lees‐Miller et al. · Cell · 1990 · 684 citations

, , +7

Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.

Donald Macleod, Jillian Charlton, John J. Mullins et al. · Genes & Development · 1994 · 592 citations · Full text

, , +16

Structural Basis for Discriminative Regulation of Gene Expression by Adenine- and Guanine-Sensing mRNAs

Alexander Serganov, Yu-Ren Yuan, Olga Pikovskaya et al. · Chemistry & Biology · 2004 · 565 citations · Full text

, , +12

1–5 of 585

Authors

2.3K

  1. KS
    Kazuhiro Sogawa

    Tohoku University, Japan

    10 publications · 1.1K citations

    10

    h-index

  2. YF
    Yoshiaki Fujii‐Kuriyama

    Tohoku University, Japan

    8 publications · 749 citations

    8

    h-index

  3. AK
    Akira Kobayashi

    Tohoku University, Japan

    6 publications · 727 citations

    6

    h-index

  4. RT
    Robert Tjian

    University of California, Berkeley, United States

    6 publications · 2.9K citations

    6

    h-index

  5. HI
    Hiroaki Imataka

    McGill University, Canada

    5 publications · 639 citations

    5

    h-index

1–5 of 2.3K

Institutions

566

  1. National Institutes of Health

    Bethesda, United States

    18 h-index

    66 publications

    3.3K citations

  2. Inserm

    Paris, France

    15 h-index

    82 publications

    3.4K citations

  3. National Cancer Institute

    Bethesda, United States

    14 h-index

    47 publications

    3.7K citations

  4. Tohoku University

    Sendai, Japan

    14 h-index

    53 publications

    5.8K citations

  5. Yale University

    New Haven, United States

    12 h-index

    27 publications

    2K citations

  6. The University of Tokyo

    Tokyo, Japan

    11 h-index

    65 publications

    7.6K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    26 publications

    5.1K citations

  8. University of California, Los Angeles

    Los Angeles, United States

    10 h-index

    30 publications

    1.7K citations

1–8 of 566

Venues

  1. Journal of Biological Chemistry

    JBC · 110 publications · 8.1K citations

    55

    h-index

  2. Molecular and Cellular Biology

    MCB · 69 publications · 4.9K citations

    40

    h-index

  3. Nucleic Acids Research

    29 publications · 1.6K citations

    23

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 21 publications · 3.6K citations

    21

    h-index

  5. Molecular Endocrinology

    21 publications · 1.1K citations

    19

    h-index

1–5