Concepedia

Framework Regions

Framework Regions is a segment of the variable domains of antibody heavy and light chains that provides a structural scaffold to support the hypervariable loops, distinguished by its relatively conserved amino acid sequence in contrast to the adjacent complementarity-determining regions.

155

Publications

10.6K

Citations

725

Authors

264

Institutions

Publications per year

2017–2026

19

Parents

Publications

155

IgBLAST: an immunoglobulin variable domain sequence analysis tool

Jian Ye, Ning Ma, Thomas Madden et al. · Nucleic Acids Research · 2013 · 1.3K citations · Full text

, , +16

Antibody framework residues affecting the conformation of the hypervariable loops

Jefferson Foote, Greg Winter · Journal of Molecular Biology · 1992 · 535 citations

, , +13

Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth.

Koh Sato, Masayuki Tsuchiya, José W. Saldanha et al. · PubMed · 1993 · 277 citations

, , +17

Analysis of the Antigen Combining Site: Correlations Between Length and Sequence Composition of the Hypervariable Loops and the Nature of the Antigen

Abigail V.J Collis, Adam Brouwer, Andrew C.R. Martin · Journal of Molecular Biology · 2002 · 254 citations

, , +15

Antibody structure determination using a combination of homology modeling, energy‐based refinement, and loop prediction

Kai Zhu, Tyler Day, Dora Toledo Warshaviak et al. · Proteins Structure Function and Bioinformatics · 2014 · 247 citations · Full text

, , +16

1–5 of 155

Authors

725

  1. PT
    Philippe Thullier

    Service de Santé des Armées, France

    5 publications · 171 citations

    5

    h-index

  2. IP
    Ira Pastan

    National Cancer Institute, United States

    5 publications · 538 citations

    5

    h-index

  3. JD
    J. Donald Capra

    The University of Texas Southwestern Medical Center, United States

    5 publications · 149 citations

    5

    h-index

  4. YR
    Yoram Reiter

    Technion – Israel Institute of Technology, Israel

    5 publications · 538 citations

    5

    h-index

  5. ML
    Marie‐Paule Lefranc

    Centre National de la Recherche Scientifique, France

    4 publications · 263 citations

    4

    h-index

1–5 of 725

Institutions

264

  1. National Institutes of Health

    Bethesda, United States

    14 h-index

    57 publications

    9.9K citations

  2. The University of Texas Southwestern Medical Center

    Dallas, United States

    7 h-index

    20 publications

    610 citations

  3. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    7 h-index

    52 publications

    2.5K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    22 publications

    1.3K citations

  5. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    5 h-index

    12 publications

    2.1K citations

  6. National Cancer Institute

    Bethesda, United States

    5 h-index

    18 publications

    2.2K citations

  7. The University of Texas Health Science Center at Houston

    Houston, United States

    5 h-index

    11 publications

    448 citations

  8. Harvard University

    Cambridge, United States

    4 h-index

    10 publications

    363 citations

1–8 of 264

Venues

  1. The Journal of Immunology

    JI · 22 publications · 1.2K citations

    18

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 10 publications · 610 citations

    10

    h-index

  3. Journal of Molecular Biology

    JMB · 7 publications · 1.2K citations

    7

    h-index

  4. The Journal of Experimental Medicine

    6 publications · 406 citations

    6

    h-index

  5. mAbs

    6 publications · 329 citations

    6

    h-index

1–5