Concepedia

Force-dependent Signaling

Force-Dependent Signaling is a biological signaling mechanism in which the activation, modulation, or propagation of intracellular signals is directly governed by mechanical forces exerted on or generated by immune cells, distinguishing it from conventional biochemical signaling by its reliance on physical cues such as tension, stiffness, or shear stress.

57

Publications

6.5K

Citations

334

Authors

157

Institutions

Publications per year

2017–2026

30

Parents

Publications

57

Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas

Yasuhiro Sawada, Masako Tamada, Benjamin J. Dubin‐Thaler et al. · Cell · 2006 · 935 citations · Full text

, , +14

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Ángel G. Alpuche‐Solís, Piotr Bielecki, Holly R. Steach et al. · Nature · 2019 · 667 citations

, , +14

Mechanisms of mechanical signaling in development and disease

Paul A. Janmey, R. Tyler Miller · Journal of Cell Science · 2010 · 459 citations

, , +17

Nanotopography Modulates Mechanotransduction of Stem Cells and Induces Differentiation through Focal Adhesion Kinase

Benjamin Kim Kiat Teo, Sum Thai Wong, Choon Kiat Lim et al. · ACS Nano · 2013 · 416 citations

, , +17

Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals

Toru Maeda, Tomoya Sakabe, Ataru Sunaga et al. · Current Biology · 2011 · 380 citations · Full text

, , +13

1–5 of 57

Authors

334

  1. MP
    Michael P. Sheetz

    Columbia University, United States

    3 publications · 1.1K citations

    3

    h-index

  2. MY
    Mingxi Yao

    National University of Singapore, Singapore

    2 publications · 165 citations

    2

    h-index

  3. JL
    Jizhong Lou

    Chinese Academy of Sciences, China

    2 publications · 178 citations

    2

    h-index

  4. GT
    Guy Tran Van Nhieu

    Inserm, France

    2 publications · 165 citations

    2

    h-index

  5. HC
    Haodong Chen

    Cardiovascular Institute of the South, United States

    2 publications · 178 citations

    2

    h-index

1–5 of 334

Institutions

157

  1. National University of Singapore

    Singapore, Singapore

    4 h-index

    17 publications

    3.6K citations

  2. Chinese Academy of Sciences

    Beijing, China

    4 h-index

    9 publications

    891 citations

  3. University of Pennsylvania

    Philadelphia, United States

    4 h-index

    6 publications

    844 citations

  4. King's College London

    London, United Kingdom

    3 h-index

    7 publications

    1.8K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    6 publications

    645 citations

  6. Chengdu Institute of Biology

    Chengdu, China

    2 h-index

    6 publications

    534 citations

  7. Columbia University

    New York, United States

    2 h-index

    8 publications

    4.9K citations

  8. Institut de Biologie Intégrative de la Cellule

    Gif-sur-Yvette, France

    2 h-index

    4 publications

    271 citations

1–8 of 157

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 517 citations

    5

    h-index

  2. PLoS ONE

    3 publications · 279 citations

    3

    h-index

  3. Biophysical Journal

    3 publications · 75 citations

    3

    h-index

  4. Nature

    3 publications · 1.3K citations

    3

    h-index

  5. Nature Communications

    2 publications · 88 citations

    2

    h-index

1–5