Concepedia

Fold Switching

Fold Switching is a rare phenomenon in protein folding dynamics wherein a single amino acid sequence adopts two or more distinct, stable tertiary structures under physiological conditions, each capable of performing different biological functions.

63

Publications

3.6K

Citations

235

Authors

100

Institutions

Publications per year

2017–2026

35

Variants

Metamorphic Protein Folding

Parents

Publications

63

Helicity Inversion in Responsive Foldamers Induced by Achiral Halide ion Guests

R.M. Meudtner, Stefan Hecht · Angewandte Chemie International Edition · 2008 · 328 citations · Full text

, , +12

Increased Diels-Alderase activity through backbone remodeling guided by Foldit players

Christopher B. Eiben, Justin B. Siegel, Jacob B. Bale et al. · Nature Biotechnology · 2012 · 316 citations

, , +14

Extant fold-switching proteins are widespread

Lauren L. Porter, Loren L. Looger · Proceedings of the National Academy of Sciences · 2018 · 216 citations

, , +11

<scp>AlphaFold2</scp> fails to predict protein fold switching

Devlina Chakravarty, Lauren L. Porter · Protein Science · 2022 · 195 citations · Full text

, , +16

What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs

Eynat Dellus-Gur, Ágnes Tóth-Petróczy, Mikael Elias et al. · Journal of Molecular Biology · 2013 · 164 citations

, , +17

1–5 of 63

Authors

235

  1. LL
    Lauren L. Porter

    National Heart Lung and Blood Institute, United States

    12 publications · 820 citations

    13

    h-index

  2. JO
    John Orban

    Advanced Bioscience Laboratories (United States), United States

    4 publications · 295 citations

    5

    h-index

  3. LL
    Loren L. Looger

    Howard Hughes Medical Institute, United States

    5 publications · 343 citations

    5

    h-index

  4. JW
    Joseph W. Schafer

    National Heart Lung and Blood Institute, United States

    3 publications · 213 citations

    4

    h-index

  5. YC
    Yihong Chen

    Central South University, China

    4 publications · 295 citations

    4

    h-index

1–5 of 235

Institutions

100

  1. National Institutes of Health

    Bethesda, United States

    13 h-index

    32 publications

    2.1K citations

  2. National Heart Lung and Blood Institute

    Bethesda, United States

    11 h-index

    17 publications

    1K citations

  3. National Center for Biotechnology Information

    Bethesda, United States

    9 h-index

    23 publications

    1.8K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    14 publications

    1.1K citations

  5. Janelia Research Campus

    Ashburn, United States

    5 h-index

    10 publications

    702 citations

  6. Advanced Bioscience Laboratories (United States)

    Rockville, United States

    4 h-index

    16 publications

    604 citations

  7. University of Maryland, College Park

    College Park, United States

    4 h-index

    11 publications

    777 citations

  8. University of Oklahoma

    Norman, United States

    3 h-index

    9 publications

    268 citations

1–8 of 100

Venues

  1. Nature Communications

    9 publications · 472 citations

    9

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 477 citations

    7

    h-index

  3. Protein Science

    PS · 5 publications · 276 citations

    6

    h-index

  4. Biopolymers

    3 publications · 66 citations

    3

    h-index

  5. Proteins Structure Function and Bioinformatics

    3 publications · 114 citations

    3

    h-index

1–5